Amniotic fluid volume responses to amnio-infusion of amniotic fluid versus lactated Ringer's solution in fetal sheep

Journal of the Society for Gynecologic Investigation
R A Brace, Cecilia Y Cheung

Abstract

The present study tested the hypothesis that an intra-amniotic infusion of amniotic fluid (AF) would produce a more sustained increase in AF volume than an infusion of lactated Ringer's solution. Five chronically catheterized, late-gestation fetal sheep were studied over two 5-day periods with AF volume measured daily. After baseline measurements on day 1, 1 L of either warmed, previously frozen AF or warmed lactated Ringer's solution was infused intra-amniotically over 60 minutes. Two days later, the other fluid was infused. During the second week, fluids were infused in the opposite order. Analysis of variance (ANOVA) was used for statistical testing. Following intra-amniotic infusion (n = 20) of 1007 +/- 7 (SE) mL of either AF or Ringer's solution, intra-amniotic retention of the infused fluid was only moderate after 1 day (37.2% +/- 7.9%, P <.001) and was not significantly different from zero after 2 days (16.5% +/- 9.5%, P =.1). There were no significant differences in AF volume following infusion of AF versus lactated Ringer's solution or the order in which they were infused. AF compositional changes were similar except that pH and bicarbonate concentration were reduced as expected immediately after lactated Ringer's solu...Continue Reading

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·P R Jang, R A Brace
Dec 1, 1988·American Journal of Obstetrics and Gynecology·W M Gilbert, R A Brace
Sep 1, 1994·American Journal of Obstetrics and Gynecology·R A BraceR Harding
Mar 30, 2000·American Journal of Obstetrics and Gynecology·L C MatsumotoR A Brace
Apr 17, 2001·American Journal of Obstetrics and Gynecology·L C MatsumotoR A Brace
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·J Job Faber, Debra F Anderson
Feb 21, 2002·American Journal of Obstetrics and Gynecology·Larry C MatsumotoCecilia Y Cheung
Oct 2, 2003·American Journal of Obstetrics and Gynecology·Ralph W Thurlow, Robert A Brace

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Citations

Apr 25, 2014·Physiological Reports·Robert A BraceCecilia Y Cheung
Apr 28, 2006·Journal of the Society for Gynecologic Investigation·Atsushi KomatsuYuji Taketani
Jul 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A BraceDebra F Anderson
Jul 23, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Neeta L Vora, Lisa Hui
Jan 2, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A BraceDebra F Anderson
Sep 5, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A BraceCecilia Y Cheung

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