Amniotic membrane transplantation in the treatment of chronic lower limb ulcers

Actas dermo-sifiliográficas
M Alsina-Gibert, S Pedregosa-Fauste

Abstract

Approximately 1% of the general population have venous or arterial lower limb ulcers. These lesions can be treated with biological skin substitutes such as cadaver skin or tissue-engineered skin equivalents, but treatment fails in 25% of cases, resulting in pain and loss of patient autonomy, as well as increased morbidity and health care costs. In the treatment of corneal ulcers, amniotic membrane has been shown to have antimicrobial and bacteriostatic properties, and to protect the wound without eliciting an immune response. The same properties have been reported in the treatment of burns and postthrombotic ulcers. To assess the effectiveness of amniotic membrane transplantation in the treatment of refractory chronic leg ulcers. Amniotic membrane was grafted onto 4 refractory ulcers in 3 patients. The mean time required for partial and complete re-epithelialization was calculated by measuring the wound area at weeks 0, 4, 8, 12, and 16. Pain intensity was assessed at the same intervals using a visual analog scale. Complete wound re-epithelialization was achieved for 1 ulcer by week 8; in the other 3 cases, there was a 50% reduction in size compared to baseline. At week 16, the mean reduction in wound size for the 4 ulcers was ...Continue Reading

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Citations

Oct 27, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Onur SönmezMesut Aydın
Apr 24, 2013·Actas dermo-sifiliográficas·R F Lafuente-Urrez, Y Gilaberte
Jun 7, 2011·Actas dermo-sifiliográficas·E Del Río
May 9, 2014·Journal of Wound Care·A FijanH Namazi
Aug 24, 2017·Stem Cells Translational Medicine·Rebecca Lim
Dec 18, 2018·Journal of Wound Care·Mónica Rodríguez ValienteGregorio Castellanos
Mar 19, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Seonguk MinDae Hun Suh

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