PMID: 32155126Mar 11, 2020Paper

Amniotic Suspension Allograft and Fetal Bovine Acellular Dermal Matrix to Treat Complex, Acute, Full-thickness Wounds: A Retrospective Analysis of Safety and Treatment Efficacy

Wounds : a Compendium of Clinical Research and Practice
Steven ThomasKatie Culpepper Mowry

Abstract

Comorbidities; inadequate vascularity; exposure of bones, tendons, or other avascular structures; and loss or removal of significant tissue volume all complicate the clinical treatment of patients with large, acute wounds. A number of amniotic tissue products are currently available for wound healing and other applications; one of these is a human amniotic suspension allograft (ASA) consisting of particulated human amniotic membrane and cells from the amniotic fluid from the same human donor. In this study, the use of ASA with a fetal-derived bovine acellular dermal matrix to promote the healing of large, acute, full-thickness wounds is evaluated. The authors herein hypothesize treatment with ASA may allow for the healing of these wounds. This study consisted of a chart review of 33 patients, with an average age of 42.2 years, and large acute wounds that were treated with a fetal-derived bovine acellular dermal matrix adsorbed with ASA. To the best of the authors' knowledge, this is the first study to date to investigate the usefulness of ASA in wound healing for large, complex, acute wounds. In this study, 30 of 33 patients were confirmed as fully healed, and 3 patients were lost to follow-up. The average wound size was 537.4 ...Continue Reading

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Wounds : a Compendium of Clinical Research and Practice
Neil H Strauss, Richard J Brietstein
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
J H HaynesR F Diegelmann
© 2021 Meta ULC. All rights reserved