Amorimia exotropica poisoning as a presumptive cause of myocardial fibrosis in cattle

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Mauro Pereira SoaresDavid Driemeier

Abstract

The current study reports the investigation on the cause of sudden deaths associated with cardiac fibrosis in cattle in northern Rio Grande do Sul, Brazil. The exclusion of known causes of bovine cardiac fibrosis as well as the absence of the plants in that region whose consumption has already been linked to the disorder motivated this investigation. The condition, which was attributed to the consumption of Amorimia exotropica, affected draft oxen, most of which died suddenly without showing any clinical signs during usual management or work. Globular hearts with white foci at their cut surfaces were the main gross findings, which corresponded microscopically from multifocal to coalescent areas of myocardial fibrosis. To confirm the condition, A. exotropica from the ranches where cattle died from the disease was dosed to rabbits, which showed similar lesions to those seen in dead cattle after receiving 10 doses of 3.6 g/kg at 4-day intervals. Electron microscopy on rabbit tissues revealed severe tumefaction of the cardiomyocytes associated with mitochondrial swelling, displacement, and rupture of the mitochondrial crests, and of the bundles of myofibrils, apart from large glycogen deposits within the sarcoplasm. It is suggested...Continue Reading

References

Feb 22, 2011·Toxicon : Official Journal of the International Society on Toxinology·Sandro V SchonsAna Lucia Schild

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Citations

Sep 17, 2013·Regulatory Toxicology and Pharmacology : RTP·Josef Finsterer, Peter Ohnsorge
Apr 15, 2014·Journal of Agricultural and Food Chemistry·Stephen T LeeCharlotte M Taylor

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