Amorphous calcium phosphate, hydroxyapatite and poly(d,l-lactic acid) composite nanofibers: Electrospinning preparation, mineralization and in vivo bone defect repair

Colloids and Surfaces. B, Biointerfaces
Hao ZhangYing-Jie Zhu

Abstract

Due to the outstanding bioactivity and biocompatibility, calcium phosphate (CaP) based materials have been widely investigated for applications in the biomedical fields. In this study, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods have been prepared and hybridized with poly(d,l-lactic acid) (PLA) to fabricate the composite nanofibers through electrospinning. The as-prepared ACP-PLA and HA-PLA composite nanofibers exhibit favorable mineralization behaviors in simulated body fluid (SBF). In the mineralization process, the ACP nanospheres and HA nanorods play an important role in the formation of HA nanosheets on the surface of composite nanofibers. The ACP-PLA and HA-PLA composite nanofibers show a high biocompatibility. The in vivo bone defect repair properties of the ACP-PLA and HA-PLA composite nanofibers are preliminarily investigated. The as-prepared ACP-PLA and HA-PLA composite nanofibers have promising applications in the biomedical fields.

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Citations

Feb 18, 2016·Stem Cells International·Azizeh-Mitra YousefiHassane Oudadesse
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Qiuyan LiGuo He
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Saeid Tajbakhsh, Faezeh Hajiali
Mar 14, 2018·Microscopy Research and Technique·Sergio AllegriniFrancisco José Correa Braga
Apr 8, 2020·Journal of Materials Science. Materials in Medicine·Muna M Kareem, K Elizabeth Tanner
Nov 9, 2019·Nanomaterials·Tanya J LevingstoneNicholas J Dunne
Jun 13, 2019·International Journal of Biomaterials·Vitus A ApalangyaTemesgen Samuel
Sep 11, 2020·Nanomaterials·Victoria Bonilla-RepresaM Olga Guerrero-Pérez
Oct 24, 2020·Bioengineering·Xinchen WuGulden Camci-Unal
Oct 14, 2019·ACS Biomaterials Science & Engineering·Ying-Jie Zhu, Bing-Qiang Lu

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