Amorphous powders for inhalation drug delivery

Advanced Drug Delivery Reviews
Lan ChenHak-Kim Chan

Abstract

For inhalation drug delivery, amorphous powder formulations offer the benefits of increased bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and expanded options of using various drugs and their combinations. However, amorphous formulations usually have poor physicochemical stability. This review focuses on inhalable amorphous powders, including the production methods, the active pharmaceutical ingredients and the excipients with a highlight on stabilization of the particles.

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Jan 25, 2017·International Journal of Pharmaceutics·Maria DorethKorbinian Löbmann
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