Amount, avidity, and specificity of antibodies to Pseudomonas aeruginosa in normal human sera.

Journal of Clinical Microbiology
J GrzybowskiM Kłos

Abstract

Seventy-two normal human sera from healthy blood donors were tested by an enzyme-linked immunosorbent assay in order to determine the amounts and avidities of immunoglobulins M and G antibodies to lipopolysaccharides of seven Fisher's immunotypes of Pseudomonas aeruginosa and to exotoxin A. The patterns of specificity for seven immunotypes in all individual sera were determined. These data show a predominance of antibodies directed to Fisher's immunotypes 7 and 4 in the human population tested and may reflect frequency of occurrence of immunotypes outside the hospital environment.

References

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Citations

Jan 1, 1997·Pathology Oncology Research : POR·Janja PolanecZlatko P Pavelic
Jul 22, 2006·Journal of Clinical Periodontology·Dongqing WangIsao Ishikawa
Mar 1, 1996·Journal of Clinical Periodontology·D S O'Dell, J L Ebersole
Apr 21, 2007·Journal of Medical Microbiology·Abbie M WeisnerTyrone L Pitt

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Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

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