Amount of fibroglandular tissue FGT and background parenchymal enhancement BPE in relation to breast cancer risk and false positives in a breast MRI screening program : A retrospective cohort study

European Radiology
Suzan VreemannRitse M Mann

Abstract

The purpose of this study is to evaluate the predictive value of the amount of fibroglandular tissue (FGT) and background parenchymal enhancement (BPE), measured at baseline on breast MRI, for breast cancer development and risk of false-positive findings in women at increased risk for breast cancer. Negative baseline MRI scans of 1533 women participating in a screening program for women at increased risk for breast cancer between January 1, 2003, and January 1, 2014, were selected. Automated tools based on deep learning were used to obtain quantitative measures of FGT and BPE. Logistic regression using forward selection was used to assess relationships between FGT, BPE, cancer detection, false-positive recall, and false-positive biopsy. Sixty cancers were detected in follow-up. FGT was only associated to short-term cancer risk; BPE was not associated with cancer risk. High FGT and BPE did lead to more false-positive recalls at baseline (OR 1.259, p = 0.050, and OR 1.475, p = 0.003) and to more frequent false-positive biopsies at baseline (OR 1.315, p = 0.049, and OR 1.807, p = 0.002), but were not predictive for false-positive findings in subsequent screening rounds. FGT and BPE, measured on baseline MRI, are not predictive for...Continue Reading

References

Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan M DomchekBarbara L Weber
Feb 3, 2006·Cancer Research·Gillian MitchellDouglas F Easton
Mar 30, 2007·CA: a Cancer Journal for Clinicians·Debbie SaslowUNKNOWN American Cancer Society Breast Cancer Advisory Group
Sep 25, 2007·Radiologic Clinics of North America·Elizabeth A Morris
Apr 5, 2008·European Radiology·R M MannC Boetes
May 25, 2010·Magnetic Resonance Imaging Clinics of North America·Virginia Molleran, Mary C Mahoney
Jul 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kavitha PassaperumaMartin J Yaffe
Dec 24, 2010·AJR. American Journal of Roentgenology·Niamh M HamblyElizabeth A Morris
Apr 16, 2011·Radiology·Valencia KingElizabeth A Morris
Mar 28, 2012·AJR. American Journal of Roentgenology·Wendy B DeMartiniConstance D Lehman
Aug 10, 2013·Magnetic Resonance Imaging Clinics of North America·Sonya D EdwardsJanie M Lee
Sep 13, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Catherine S GiessRobyn L Birdwell
Oct 30, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M C Pike, C L Pearce
Oct 22, 2013·The Lancet Oncology·Martin WidschwendterIan J Jacobs
Nov 6, 2013·Breast Cancer Research : BCR·Kimberly A BertrandCeline M Vachon
Dec 24, 2014·Medical Image Analysis·Albert Gubern-MéridaBram Platel
Jan 7, 2015·IEEE Journal of Biomedical and Health Informatics·Albert Gubern-MéridaNico Karssemeijer
Feb 27, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kimberly A BertrandCeline M Vachon
Apr 24, 2015·AJR. American Journal of Roentgenology·Lars J GrimmSujata V Ghate
Nov 26, 2015·Magnetic Resonance Imaging·Michele TelegrafoMarco Moschetta
Jul 6, 2016·PloS One·Barbara Bennani-BaitiPascal Andreas Baltzer
Aug 1, 2016·Magnetic Resonance Imaging·Barbara Bennani-Baiti, Pascal A Baltzer
Dec 25, 2016·Breast Cancer Research and Treatment·Johanna O P WandersNico Karssemeijer
Dec 31, 2016·Medical Physics·Mehmet Ufuk DalmışAlbert Gubern-Mérida
Apr 27, 2017·Breast Cancer Research and Treatment·Jessica A Cintolo-GonzalezKevin S Hughes
Aug 10, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bas H M van der VeldenKenneth G A Gilhuijs

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Citations

Jun 4, 2020·Journal of Magnetic Resonance Imaging : JMRI·Bas H M van der VeldenKenneth G A Gilhuijs
Feb 15, 2020·European Radiology·Gary H ChangVijaya B Kolachalama

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