Amount of left ventricular hypertrophy determines the plasma N-terminal pro-brain natriuretic peptide level in patients with hypertrophic cardiomyopathy and normal left ventricular ejection fraction.

Clinical Cardiology
Seon Woon KimEun-Seok Jeon

Abstract

N-terminal pro-brain natriuretic peptide (NT-proBNP) is increased in patients with hypertrophic cardiomyopathy (HCM); however, the determinants of NT-proBNP level have not been clarified in HCM. This study was performed to determine the relationship between NT-proBNP levels and various echocardiographic variables of patients with HCM and normal left ventricular ejection fraction (LVEF). We assessed plasma NT-proBNP levels and echocardiographic variables of 36 patients (19 men, 58 +/- 14 years) with HCM and an LVEF of > or = 55%. Echocardiographic variables measured were LV wall thickness, end-diastolic LV internal dimension (LVIDd) and volume (LVEDV), LV mass, and LV mass index (LV mass/body surface area, LVMI). Left ventricular outflow tract pressure gradient, transmitral E and A velocities, deceleration time (DT) of the transmitral E wave, and septal annular E' velocity were measured by Doppler technique. The relationship between echocardiographic variables and plasma NT-proBNP level was analyzed. The plasma NT-proBNP level was 775.2 +/- 994.2 pg/ml (range 33.1-4729.0 pg/ml). It showed positive correlations with LV end-diastolic septal thickness (r = 0.39, p = 0.010) and LVMI (r = 0.27, p = 0.050), while it revealed negative ...Continue Reading

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Citations

Nov 3, 2010·Journal of Feline Medicine and Surgery·Manreet K SinghMark D Kittleson
Apr 28, 2009·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Adonia HsuAnna Paling
Feb 22, 2008·The American Journal of Cardiology·Aaron L BaggishJames L Januzzi
Apr 23, 2013·Journal of the American College of Cardiology·Jeffrey B GeskePaul Sorajja
Jul 29, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Pier Paolo BassareoGiuseppe Mercuro
Dec 10, 2019·Journal of Veterinary Internal Medicine·Chloё L Block, Mark A Oyama

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