Amount of Testosterone on Laundered Clothing After Use of Testosterone Topical 2% Solution by Healthy Male Volunteers

The Journal of Sexual Medicine
Darlene K SatoninDavid S Small

Abstract

Testosterone 2% solution (Axiron) applied to armpit(s) is used for replacement therapy in men with a deficiency of endogenous testosterone. To determine the amount of testosterone on subjects' T-shirts 12 hours after applying testosterone solution, the residual testosterone on subjects' T-shirts after laundering, and the testosterone transferred to unworn textile items during laundering with worn T-shirts. Healthy males ≥18 years old applied 2 × 1.5 mL of testosterone 2% solution to both axillae (total testosterone dose: 120 mg) and dressed in cotton long-sleeved T-shirts after a ≥3-minute waiting period. T-shirts were worn 12 hours before being removed and cut into halves, after which a 10 × 10 cm sample of each armpit area was excised for testosterone quantification before or after laundering with samples of unworn textiles. Testosterone on worn T-shirts before and after laundering, and on unworn textiles laundered with the worn T-shirts. Twelve subjects enrolled and completed, with only minor adverse events. Mean testosterone in unwashed worn T-shirts was 7603 μg, with high between-subject variability (3359 μg to 13,069 μg), representing 13% of the dose to 1 armpit. Mean testosterone in worn, laundered T-shirts was 260 μg (7...Continue Reading

References

Feb 15, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sherry Lynn Franklin, Mitchell E Geffner
Jul 3, 2004·Pediatrics·Gregory J KunzKenneth Lee Jones
Jun 21, 2007·Clinical Pediatrics·Samar K BhowmickKenneth R Rettig
Dec 22, 2011·Current Medical Research and Opinion·Michael G MillerTroy L Zumbrunnen

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