PMID: 11314884Apr 21, 2001Paper

Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study

Journal of Clinical Periodontology
E G WinkelG A van der Weijden

Abstract

The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement. 49 patients with a diagnosis of generalised severe periodontitis participated in the study. Random assignment resulted in 26 patients in the placebo (P) group with a mean age of 40 years and 23 patients in the test (T) group which had a mean age of 45 years. Clinical measurements and microbiological assessments were taken at baseline and 3 months after completion of initial periodontal therapy with additional placebo or antibiotic treatment. Patients received coded study medication of either 375 mg amoxicillin in combination with 250 mg metronidazole or identical placebo tablets, every 8 hours for the following 7 days. At baseline, no statistically significant differences between groups were found for any of the clinical parameters. Except for the plaque, there was a significantly larger change in the bleeding, probing pocket depth (PPD) and clinical attachment level (CAL) in the T-group as compared to the P-group after therapy. The greatest reduction in PPD was found at sites with initial PP...Continue Reading

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Citations

Oct 6, 2010·Antimicrobial Agents and Chemotherapy·Hiroyo IkaiMasahiro Kohno
Feb 20, 2004·Annals of Periodontology·Anne D HaffajeeJohn C Gunsolley
Jun 8, 2001·Journal of Periodontology·A J van WinkelhoffW A van der Reijden
Nov 6, 2002·Journal of Periodontology·Clay Walker, Katherine Karpinia
Jun 27, 2002·Journal of Periodontology·Rainer BuchmannDieter E Lange
Jan 7, 2005·Journal of Periodontology·Jørgen Slots, UNKNOWN Research, Science and Therapy Committee
Apr 8, 2004·Journal of Periodontology·Georgia K Johnson, Margaret Hill
Oct 7, 2008·Journal of Periodontology·Arndt GuentschSigrun Eick
Dec 5, 2008·Journal of Periodontology·Jason D JohnsonJoel D Rudney
Aug 7, 2009·Journal of Periodontology·Erica Del Peloso RibeiroMárcio Zaffalon Casati
Oct 2, 2009·Journal of Periodontology·Arie J van Winkelhoff, Edwin G Winkel
Jun 2, 2011·Journal of Periodontology·Rupal A PatelRichard M Palmer
May 22, 2013·Journal of Periodontology·Thomas E RamsArie J van Winkelhoff
May 15, 2013·Journal of Oral Microbiology·Orit Oettinger-BarakEric C Reynolds
Apr 19, 2013·Journal of Periodontology·Monika Astasov-FrauenhofferTuomas Waltimo
May 30, 2014·Journal of Indian Society of Periodontology·Arvind ShettyRukshit Kadakia
Oct 23, 2002·Journal of Clinical Periodontology·M FeresS S Socransky
Nov 26, 2002·Journal of Clinical Periodontology·B G LoosU van der Velden
Jan 10, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Markus ReiseBernd W Sigusch
Nov 25, 2011·Advances in Medical Sciences·A LeszczyńskaM Pietruska
Jan 8, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F S MartelliE Medico
Jan 28, 2010·Dental Clinics of North America·Joe W KrayerKeith L Kirkwood
May 19, 2009·International Journal of Medical Microbiology : IJMM·Giuseppe ValenzaUlrich Vogel
Sep 2, 2005·Periodontology 2000·G Rutger Persson
Sep 2, 2005·Periodontology 2000·Arie J van Winkelhoff, Edwin G Winkel
Sep 22, 2005·Journal of Clinical Periodontology·A J van Winkelhoff

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