Amoxicillin rash in patients with infectious mononucleosis: evidence of true drug sensitization

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Katinka Ónodi-NagyZsuzsanna Bata-Csörgő

Abstract

It hasn't been clearly understood yet whether sensitization to antibiotics, the virus itself or transient loss of drug tolerance due to the virus, is responsible for the development of maculopapular exanthems following amoxicillin intake in patients with infectious mononucleosis. We aimed to examine whether sensitization to penicillin developed among patients with skin rash following amoxicillin treatment within infectious mononucleosis. Ten patients were investigated for drug sensitization by lymphocyte transformation test and six patients were further tested by prick-, intradermal and patch tests employing the penicillin's main antigens. Lymphocyte transformation test showed negative results with amoxicillin, while one patient had positive reaction to cefixime. Six patients with suspected sensitization to amoxicillin were then investigated by in vivo tests. Prick tests were negative in all six patients, but the intradermal tests showed positive reactions in four patients. Our data demonstrate that in vitro testing is not sensitive enough in determining drug sensitization to penicillin. In vivo tests should be performed to detect sensitization and indeed with skin tests our results confirmed that sensitization to aminopenicill...Continue Reading

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Citations

Oct 27, 2016·Current Opinion in Infectious Diseases·Katherine C KonvinseJason A Trubiano
Nov 2, 2016·Current Opinion in Pulmonary Medicine·Manali MukherjeeParameswaran Nair
Sep 14, 2016·The Annals of Pharmacotherapy·Dennis F Thompson, Carroll L Ramos
Oct 6, 2018·Clinical Pediatrics·Nyomi R WashingtonMaureen Petersen
Aug 15, 2017·Case Reports in Plastic Surgery & Hand Surgery·Antoine HomsyAli Modarressi
Mar 28, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Lubnaa HossenbaccusAnne K Ellis
Mar 30, 2021·Frontiers in Pharmacology·Eleonora AnciJean-Christoph Caubet
Oct 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Rannakoe J LehloenyaElizabeth J Phillips

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