Amoxicillin-sulbactam: A clinical and therapeutic review

Drugs of Today
C. Acuna, X. Rabasseda

Abstract

Combinations of beta-lactamase inhibitors with penicillins, especially aminopenicillins, have broad-spectrum antibacterial activity against most of the common pathogens of the respiratory and urinary tracts. This means that they are an ideal treatment for infections such as otitis media, sinusitis, special cases of pharyngeal tonsillitis (recurring forms, indirect pathogenic action, or after the failure of amoxicillin monotherapy), acute exacerbations of chronic bronchitis, cystitis, urethritis, etc. The amoxicillin-sulbactam combination is active against both beta-lactamase producer and nonproducer strains, and is effective against Gram-positive cocci (Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus of nonhospital origin), Gram-negative cocci (Neisseria gonorrhoeae, Moraxella catarrhalis and others), Gram-negative bacilli (nonhospital strains of Haemophilus influenzae, Escherichia coli and Klebsiella pneumoniae and others) and anaerobes. Its antimicrobial activity means that it is indicated in the treatment of respiratory, ear, nose and throat, urinary, dermatological and gynecological infections caused by susceptible germs, as well as in a variety of surgical situations (both as a treatment and as prop...Continue Reading

Citations

Nov 28, 2007·Expert Review of Anti-infective Therapy·Itzhak Brook
Aug 2, 2006·Angewandte Chemie·Franz von NussbaumDieter Häbich
Apr 22, 2011·Expert Opinion on Pharmacotherapy·Itzhak Brook
Jul 5, 2013·Clinical Microbiology Reviews·Itzhak BrookEllie J C Goldstein
Sep 15, 2015·Journal of Chemotherapy·Itzhak Brook

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