AMP-activated protein kinase and its downstream transcriptional pathways.

Cellular and Molecular Life Sciences : CMLS
Carles Cantó, Johan Auwerx

Abstract

The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place through the acute modulation of key metabolic enzymes via direct phosphorylation, but also through a slower transcriptional adaptative response. The question of how AMPK regulates the expression of a number of gene sets, such as those related to mitochondrial biogenesis, energy production and oxidative protection, is only beginning to be elucidated, and still many questions remain to be answered. In this review we will try to integrate our current knowledge on how AMPK regulates transcription in muscle and liver, which will serve as examples to illustrate the major advances in the field and the key challenges ahead.

References

Jan 1, 1976·Medicine and Science in Sports·D L CostillM L Pollock
Nov 1, 1966·The Journal of Clinical Investigation·G F CahillD M Kipnis
May 16, 1997·The Journal of Biological Chemistry·D VavvasN B Ruderman
Dec 18, 1998·The Journal of Biological Chemistry·B E CruteL A Witters
Mar 4, 2000·Progress in Nucleic Acid Research and Molecular Biology·D De Cesare, P Sassone-Corsi
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·J LuE N Olson
Apr 5, 2000·The Journal of Biological Chemistry·C LemercierS Khochbin
May 20, 2000·FEBS Letters·M D LeibowitzJ Auwerx
Jun 14, 2000·Journal of Applied Physiology·W W WinderJ O Holloszy
Jul 6, 2000·British Journal of Pharmacology·J Zheng, V D Ramirez
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·L F MichaelB M Spiegelman
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·H YamashitaK Uyeda
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·B Mayr, M Montminy
Sep 5, 2001·Current Opinion in Genetics & Development·T A McKinseyE N Olson
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Oct 24, 2001·Cell·H VaziriR A Weinberg
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D G Hardie, S A Hawley
Sep 26, 2002·The Journal of Biological Chemistry·Kevin J BittermanDavid A Sinclair
Nov 21, 2002·Biochemical Society Transactions·D G Hardie, D A Pan
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Haihong ZongGerald I Shulman
Dec 7, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Keith BaarJohn O Holloszy
Jan 4, 2003·The Journal of Clinical Investigation·Benoit ViolletSophie Vaulont

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Citations

Mar 25, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero SalminenKai Kaarniranta
Mar 7, 2012·Journal of Neural Transmission·Akira OtaMiyuki Ota
Jan 30, 2013·Molecular Aspects of Medicine·Carles CantóPeter Bai
Sep 20, 2011·Cellular & Molecular Immunology·Hun-Taeg Chung
Sep 6, 2011·Nature Cell Biology·Maria M Mihaylova, Reuben J Shaw
May 15, 2013·Nature Reviews. Drug Discovery·Pénélope A AndreuxJohan Auwerx
Mar 8, 2012·Nature Reviews. Molecular Cell Biology·Riekelt H HoutkooperJohan Auwerx
Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Laura J TerryThomas Shenk
Apr 2, 2011·The Journal of Biological Chemistry·Jun-Xing ZhaoMin Du
May 11, 2011·Antioxidants & Redox Signaling·Lucia BiasuttoMario Zoratti
Oct 5, 2011·Antioxidants & Redox Signaling·Valeria Gabriela Antico ArciuchMaría Cecilia Carreras
Dec 6, 2011·Omics : a Journal of Integrative Biology·Anna KulikGrażyna Dobrowolska
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Brian J Altman, Jeffrey C Rathmell
Nov 23, 2011·Pharmacological Reviews·Carles Cantó, Johan Auwerx
Aug 16, 2011·Physiology·Carles Cantó, Johan Auwerx
Oct 27, 2011·Experimental Diabetes Research·Yuki TanakaDaisuke Koya
Mar 13, 2012·Cancer Prevention Research·Nanthakumar SubramaniamMichael Downes
Oct 21, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos Fernández-Hernando, Kathryn J Moore
Jun 8, 2011·The Journal of Veterinary Medical Science·Yoshinori TakeuchiHajime Tsujimoto
Sep 10, 2011·The Journal of Endocrinology·J JeyabalanC Chenu
Jan 29, 2014·The Journal of Endocrinology·Claudia E Robert-CoopermanBrant R Burkhardt
Jan 15, 2013·Biochimica Et Biophysica Acta·Russell H SwerdlowJianghua Lu
Feb 19, 2013·EMBO Molecular Medicine·Gizem Donmez, Tiago F Outeiro
Jul 20, 2011·Nature Chemical Biology·David CarlingSteven J Gamblin
Mar 14, 2014·EMBO Molecular Medicine·Arwen W GaoRiekelt H Houtkooper
Oct 26, 2012·Molecular Membrane Biology·Alessandra FerrariMaurizio Crestani
Jul 21, 2015·International Journal of Molecular Sciences·Janina A VaitkusFrancesco S Celi
Aug 4, 2012·Endocrine Research·Alejandro J de la TorrePerrin C White
Nov 26, 2015·The Proceedings of the Nutrition Society·I Rodriguez-RamiroA M Minihane
Apr 23, 2016·International Journal of Experimental Pathology·Maria Esméria C AmaralHelena C Barbosa-Sampaio
Oct 30, 2012·Free Radical Biology & Medicine·Brian J Morris

❮ Previous
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