AMPA receptor activation and phosphatase inhibition affect neonatal rat respiratory rhythm generation

The Journal of Physiology
Q Ge, J L Feldman

Abstract

1. We investigated the role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors and their regulation in affecting respiratory-related neurones in a neonatal rat medullary slice that spontaneously generates respiratory-related rhythm and motor output in the hypoglossal (XII) nerve. 2. Bath application of the AMPA receptor antagonist 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2, 3-benzodiazepine (GYKI) completely blocked XII nerve activity, as well as respiratory-related synaptic drives in neurones within the preBötzinger Complex (preBotC), site of rhythm generation in the slice. 3. Local application of GYKI to the preBötC blocked respiratory rhythm. Local application of AMPA to the preBötC increased rhythm frequency and depolarized respiratory-related neurones. 4. In the presence of tetrodotoxin (TTX), GYKI completely blocked the inward current induced by local application of AMPA, but not that induced by kainate. 5. Local application of okadaic acid, a membrane-permeable inhibitor of phosphatase 1 and 2A, to the preBotC increased the frequency of respiratory motor discharge. 6. Intracellular application of microcystin, a membrane-impermeable inhibitor of phosphatase 1 and 2A, enhanced endogenous inspi...Continue Reading

References

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Citations

Apr 23, 2008·Journal of Computational Neuroscience·William H NessePaul C Bressloff
Jun 14, 2005·Respiratory Physiology & Neurobiology·Narong Simakajornboon, Teeradej Kuptanon
Apr 17, 2002·The Journal of Physiology·R J A WilsonJ E Remmers
Aug 5, 2009·Respiratory Physiology & Neurobiology·Jason Q Pilarski, Ralph F Fregosi
May 19, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yonglu Huang, Harry G Goshgarian
May 7, 2009·Experimental Neurology·Yonglu Huang, Harry G Goshgarian
Aug 12, 2008·Respiratory Physiology & Neurobiology·P M MacFarlaneG S Mitchell
Nov 27, 2008·The European Journal of Neuroscience·Ryland W Pace, Christopher A Del Negro
May 29, 2016·Sleep Medicine Clinics·Shahrokh JavaheriJohn J Greer
Jul 23, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·J Muñoz-OrtizC Morgado-Valle
Aug 19, 2017·Scientific Reports·John A HayesChristopher A Del Negro
Oct 25, 2007·Biochemical Society Transactions·J E R WilkersonG S Mitchell
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G M WhitneyD Gozal
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Jul 6, 2021·Respiratory Physiology & Neurobiology·Elenia CinelliFulvia Bongianni

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