AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization

Molecular and Cellular Neurosciences
Eric Jacobi, Jakob von Engelhardt

Abstract

Fast excitatory transmission at synapses of the central nervous system is mainly mediated by AMPA receptors (AMPARs). Synaptic AMPAR number and function correlates with synaptic strength. AMPARs are thus key proteins of activity-dependent plasticity in neuronal communication. Up- or down-regulation of synaptic AMPAR number is a tightly controlled dynamic process that involves export of receptors from the endoplasmic reticulum (ER) and Golgi apparatus, exocytosis and endocytosis as well as lateral diffusion of the receptors in the cell membrane. The four AMPAR subunits are embedded into a dynamic network of more than 30 interacting proteins. Many of these proteins are known to modulate receptor gating, trafficking and subcellular localization. Here, we will review the influence that AMPAR interacting proteins exert on trafficking and subcellular localization of the receptors by controlling their assembly, ER/Golgi apparatus export, and synaptic anchoring.

Citations

Jul 7, 2020·The Journal of Physiology·Eric Jacobi, Jakob von Engelhardt
Sep 16, 2020·The Journal of Cell Biology·Maria CasasNúria Casals
Sep 28, 2018·International Journal of Environmental Research and Public Health·Thomas Heinbockel, Antonei B Csoka
Dec 21, 2018·Frontiers in Molecular Neuroscience·Gabrielle T Parkinson, Jonathan G Hanley
Feb 24, 2020·GeroScience·Yin ZhaoXin A Zhang
Oct 27, 2018·Frontiers in Cellular Neuroscience·Jonathan G Hanley
Mar 27, 2019·International Journal of Molecular Sciences·Jakob von Engelhardt
Nov 10, 2020·ELife·Shawn M LamotheHarley T Kurata
Nov 14, 2020·Progress in Lipid Research·Rut FadóNúria Casals
Jul 17, 2021·Neuropharmacology·Peter M MatthewsIngo H Greger

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