AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence

Neuropharmacology
Xiaoyu HuZaijie Jim Wang

Abstract

Development of opioid tolerance and dependence hinders the use of opioids for the treatment of chronic pain. In searching for the mechanism and potential intervention for opioid tolerance and dependence, we studied the action of two positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR PAMs). In mice treated with morphine (100 mg/kg, s.c.), acute morphine tolerance and dependence developed in 4-6 h. Treatment with aniracetam, a well-established AMPAR PAM, was able to completely prevent and reverse the development of acute antinociceptive tolerance to morphine. Partial, but significant, effects of aniracetam on acute morphine induced-physical dependence were also observed. Moreover, aniracetam significantly reversed the established morphine tolerance and dependence in a chronic model of morphine tolerance and dependence produced by intermittent morphine (10 mg/kg, s.c. for 5d). In addition, HJC0122, a new AMPAR PAM was found to have similar effects as aniracetam but with a higher potency. These previously undisclosed actions of AMPAR PAMs are intriguing and may shed lights on understanding the APMA signaling pathway in opioid addiction. Moreover, these data suggest that AMPAR ...Continue Reading

References

Jan 1, 1984·Annual Review of Neuroscience·A I Basbaum, H L Fields
Nov 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K RasmussenG K Aghajanian
Oct 21, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K LutfyE Weber
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Yun GuanKe Ren
Oct 24, 2002·Trends in Neurosciences·Insuk Song, Richard L Huganir
Dec 14, 2002·The Clinical Journal of Pain·Charles E Inturrisi
Nov 25, 2004·Schizophrenia Research·Harri J TuominenKristian Wahlbeck
Mar 2, 2005·European Journal of Pain : EJP·Jürgen Jage
Dec 20, 2005·Current Opinion in Pharmacology·Gary Lynch
Jul 25, 2006·Pharmacoepidemiology and Drug Safety·Leonard J PaulozziYongli Xi
Sep 16, 2006·American Journal of Respiratory and Critical Care Medicine·Jun RenJohn J Greer
May 17, 2007·Current Drug Targets·A C Arai, M Kessler
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia VaglenovaClark Randal
Jul 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui XuMin Zhuo
Jan 17, 2009·Brain Research Reviews·M M HeinricherB M Lumb
Mar 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Danielle A SimmonsGary Lynch
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan ChenZaijie Jim Wang
Mar 26, 2011·The Journal of Pharmacology and Experimental Therapeutics·Cheng YangZaijie Jim Wang
Aug 23, 2011·Seminars in Cell & Developmental Biology·Hey-Kyoung Lee, Alfredo Kirkwood
Dec 18, 2014·The Journal of Pharmacology and Experimental Therapeutics·Xiaoyu HuZaijie Jim Wang
Jul 2, 2016·Current Topics in Medicinal Chemistry·Tristan ReuillonPaul Beswick
Oct 19, 2016·Anesthesiology·Chen SuJing Wang

❮ Previous
Next ❯

Citations

Nov 27, 2019·Doklady. Biochemistry and Biophysics·V V GrigorievS O Bachurin
Jun 24, 2020·Peptides·Richard J Bodnar
Feb 18, 2021·Behavioural Pharmacology·Brionna D Davis-ReyesNoelle C Anastasio
Oct 8, 2021·Bulletin of Experimental Biology and Medicine·N S Sorokina, M V Starostina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.