AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats.

Neuroscience
Kenneth D CarrEdward B Ziff

Abstract

Previous findings suggest that neuroadaptations downstream of D-1 dopamine (DA) receptor stimulation in nucleus accumbens (NAc) are involved in the enhancement of drug reward by chronic food restriction (FR). Given the high co-expression of D-1 and GluR1 AMPA receptors in NAc, and the regulation of GluR1 channel conductance and trafficking by D-1-linked intracellular signaling cascades, the present study examined effects of the D-1 agonist, SKF-82958, on NAc GluR1 phosphorylation, intracranial electrical self-stimulation reward (ICSS), and reversibility of reward effects by a polyamine GluR1 antagonist, 1-NA-spermine, in ad libitum fed (AL) and FR rats. Systemically administered SKF-82958, or brief ingestion of a 10% sucrose solution, increased NAc GluR1 phosphorylation on Ser845, but not Ser831, with a greater effect in FR than AL rats. Microinjection of SKF-82958 in NAc shell produced a reward-potentiating effect that was greater in FR than AL rats, and was reversed by co-injection of 1-NA-spermine. GluR1 abundance in whole cell and synaptosomal fractions of NAc did not differ between feeding groups, and microinjection of AMPA, while affecting ICSS, did not exert greater effects in FR than AL rats. These results suggest a rol...Continue Reading

References

Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·F E PontieriG Di Chiara
Jan 1, 1996·Annual Review of Neuroscience·R A Wise
Jul 23, 1999·Annals of the New York Academy of Sciences·H J GroenewegenP Voorn
Jun 7, 2002·Current Opinion in Neurobiology·Michael F Barry, Edward B Ziff
Nov 19, 2003·The European Journal of Neuroscience·Cristina CadoniGaetano Di Chiara
Jul 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nobuyoshi SutoPaul Vezina
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Apr 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey W DalleyTrevor W Robbins
Apr 28, 2005·Nature Neuroscience·Nora D Volkow, Roy A Wise
Mar 7, 2006·Brain Research·Juan ZhenKenneth D Carr
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
Jan 24, 2007·Nature Reviews. Neuroscience·Victor A DerkachThomas R Soderling
Mar 23, 2007·Annual Review of Neuroscience·Howard L FieldsSaleem M Nicola
Sep 4, 2007·Pharmacology, Biochemistry, and Behavior·Paul J WellmanKristina W Davis
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiu SunMarina E Wolf
Apr 24, 2008·The European Journal of Neuroscience·Ryan K BachtellDavid W Self
Aug 5, 2008·Neuropharmacology·Peter W KalivasHaowei Shen
Sep 13, 2008·Trends in Neurosciences·Yukiori Goto, Anthony A Grace
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katie R FamousR Christopher Pierce
Jul 3, 2009·Nature Reviews. Neuroscience·Peter W Kalivas

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Citations

Apr 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David S TukeyEdward B Ziff
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yossef GofferJing Wang
Aug 22, 2013·Current Psychiatry Reports·Guido K W Frank
Sep 1, 2012·Expert Opinion on Medical Diagnostics·Guido K W Frank
Oct 12, 2010·Medical Hypotheses·Albert Stuart Reece
Oct 13, 2012·Journal of Pharmacological Sciences·Hiroko IkedaAlexander R Cools
Oct 19, 2016·Anesthesiology·Chen SuJing Wang
Nov 9, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tracey M D'CunhaUri Shalev
Jan 24, 2017·The European Journal of Neuroscience·Jiangyong OuyangKenneth D Carr
Feb 6, 2020·Current Pharmaceutical Design·Kenneth D Carr
Jul 22, 2018·BioMed Research International·Larisa Montalvo-MartínezAlberto Camacho

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