AMPA-receptor trafficking and injury-induced cell death.

The European Journal of Neuroscience
Michael S BeattieJacqueline C Bresnahan

Abstract

AMPA receptors (AMPARs) are critical for synaptic plasticity, and are subject to alterations based on subunit composition and receptor trafficking to and from the plasma membrane. One of the most potent regulators of AMPAR trafficking is the pro-inflammatory cytokine tumor necrosis factor (TNF)α, which is involved in physiological regulation of synaptic strength (Beattie et al., (2002) Science, 295, 2282-2285; Stellwagen and Malenka, (2006) Nature, 440, 1054-1059) and is also present at high concentrations after CNS injury. Here, we review evidence that TNF can rapidly alter the surface expression of AMPARs so that the proportion of Ca(++) -permeable receptors is increased and that this increase, in combination with increased levels of extracellular glutamate after injury, plays an important role in enhancing excitotoxic cell death after CNS injury. Thus, the pathophysiological hijacking of a critical regulator of synaptic plasticity and homeostasis by the secondary injury cascade may represent a new therapeutic target for neuroprotection.

References

Nov 1, 1992·Journal of Neurobiology·D W Choi
Sep 1, 1996·Journal of Neuroimmunology·C X WangJ Gybels
Dec 29, 1999·Nature Medicine·D PittC S Raine
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·G S EmchR C Rogers
Mar 16, 2001·Trends in Neurosciences·C MatuteM V Sánchez-Gómez
Mar 22, 2001·Experimental Neurology·S D GrossmanJ R Wrathall
Mar 23, 2002·Science·Eric C BeattieRobert C Malenka
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
Jun 26, 2004·Annual Review of Neuroscience·V Reggie EdgertonRoland R Roy
Jul 20, 2004·Nature Medicine·Xiaohai WangMaiken Nedergaard
Sep 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Barbara J BlanchardVernon M Ingram
Nov 30, 2004·Trends in Molecular Medicine·Michael S Beattie
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David StellwagenRobert C Malenka
Apr 22, 2005·Neuroscience Letters·Camilla I SvenssonLinda S Sorkin
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liliana BernardinoJens Zimmer
Nov 24, 2005·The Journal of Pharmacology and Experimental Therapeutics·Tiziana GenoveseSalvatore Cuzzocrea
Dec 21, 2005·Neuron·Hillel AdesnikPamela M England
Jan 25, 2006·Journal of Neurotrauma·John C GenselJacqueline C Bresnahan
Mar 21, 2006·Nature·David Stellwagen, Robert C Malenka
May 19, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Baosong LiuQi Wan
Jun 30, 2006·Journal of Neurochemistry·Huei-Sheng Vincent Chen, Stuart A Lipton
Aug 26, 2006·Trends in Molecular Medicine·Gina G Turrigiano
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chen LaiHuaibin Cai
Dec 16, 2006·Progress in Brain Research·Jonathan R Wolpaw
Jan 24, 2007·Nature Reviews. Neuroscience·Victor A DerkachThomas R Soderling
Feb 21, 2007·Nature Neuroscience·Pascal JourdainAndrea Volterra
Apr 25, 2007·Current Opinion in Neurobiology·Gina Turrigiano
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kurt C MarsdenReed C Carroll
Jan 11, 2008·Journal of Neuroinflammation·Edward L Tobinick, Hyman Gross
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dmitri LeonoudakisEric C Beattie
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jianrong LiPaul A Rosenberg
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Max Larsson, Jonas Broman

❮ Previous
Next ❯

Citations

Jan 17, 2013·Journal of Medicinal Chemistry·Mette H PoulsenKristian Strømgaard
Mar 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Larissa A Jarzylo, Heng-Ye Man
Jun 27, 2014·Mediators of Inflammation·Gabriel Olmos, Jerònia Lladó
Dec 27, 2013·International Journal of Cell Biology·Assunta SenatoreRoberto Chiesa
Sep 17, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna L XavierMaiken Nedergaard
May 21, 2014·Experimental Neurology·Kasper C D Roet, Joost Verhaagen
Jun 1, 2011·The EPMA Journal·Paola MoralesEdgardo Rojas-Mancilla
Jul 4, 2012·Trends in Neurosciences·Mirko Santello, Andrea Volterra
Dec 14, 2011·Progress in Retinal and Eye Research·Mohammadali AlmasiehAdriana Di Polo
Mar 30, 2011·Pharmacology, Biochemistry, and Behavior·Irma E Holopainen, Hanna B Laurén
Mar 12, 2011·Neuropharmacology·Dewleen G BakerDaniel T O'Connor
Oct 16, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Genoveva UzunovaEric Hollander
Sep 18, 2012·Behavioural Brain Research·Kevin C HoyJames W Grau
Jan 5, 2012·Frontiers in Neuroendocrinology·Michael A GalicQuentin J Pittman
Mar 17, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Valerie JeanneretManuel Yepes
Nov 6, 2018·International Journal of Molecular Sciences·Yilin MaoMelinda Fitzgerald
Feb 3, 2019·Radiologic Clinics of North America·Jason F TalbottSanjay S Dhall
Jul 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh AbbaszadehHaroon Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.