AMPA receptor trafficking and learning.

The European Journal of Neuroscience
J Keifer, Z Zheng

Abstract

In the last few years it has become clear that AMPA-type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory, as well as disease states involving cognitive dysfunction. Here, we summarize the evidence for AMPAR trafficking as a mechanism underlying a variety of learned responses derived from both behavioral and cellular studies. Evidence is also reviewed supporting synaptic dysfunction related to impaired AMPAR trafficking as a mechanism underlying learning and memory deficits in Alzheimer's disease. We conclude that emerging data support the concept of multistage AMPAR trafficking during learning and that a broad approach to include examination of all of the AMPAR subunits will provide a more complete view of the mechanisms underlying multiple forms of learning.

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Citations

Mar 26, 2011·Journal of Molecular Neuroscience : MN·Boris SabirzhanovJoyce Keifer
Nov 2, 2012·The Journal of Biological Chemistry·Swarna RamaswamyVasanthi Jayaraman
Apr 4, 2012·PloS One·Guiscard SeebohmNathalie Strutz-Seebohm
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xuan LiMarina E Wolf
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James A BibbCristina M Alberini
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei LiJoyce Keifer
Apr 1, 2011·Neurodegenerative Disease Management·Giselle M PetzingerMichael W Jakowec
Jan 10, 2014·Journal of Neural Transmission·Jessica A PanzerDavid R Lynch
Mar 26, 2014·Neurotoxicology·Barbara VivianiMarina Marinovich
Jan 21, 2014·Journal of Molecular Neuroscience : MN·Ganesh AmbigapathyJoyce Keifer
Mar 12, 2013·Cellular and Molecular Life Sciences : CMLS·Silvia BassaniMaria Passafaro
Jul 19, 2011·Trends in Neurosciences·Charles L PickensYavin Shaham
Jun 23, 2011·The European Journal of Neuroscience·Xuan Li, Marina E Wolf
Feb 26, 2013·Synapse·Marylène C Focant, Emmanuel Hermans
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Jan 1, 2012·Biomolecules & Therapeutics·Maria D RubioJames H Meador-Woodruff
Aug 17, 2019·Traffic·Vina Tikiyani, Kavita Babu

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