AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise

Neurochemical Research
Tim A Benke, Stephen F Traynelis

Abstract

Twenty years ago, we reported from the Collingridge Lab that a single-channel conductance increase through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type ionotropic glutamate receptors (AMPARs) could mediate one form of plasticity associated with long-term potentiation (LTP) in the hippocampus (Benke et al., Nature 395:793-797, 1998). Revealed through peak-scaled non-stationary fluctuation analysis (PS-NSFA, also known as noise analysis), this component of LTP could be exclusively mediated by direct increases in channel conductance or by increases in the number of high conductance synaptic AMPARs. Re-evaluation of our original data in the light of the molecular details regarding AMPARs, conductance changes and plasticity suggests that insertion of high-conductance GluA1 homomers can account for our initial findings. Any potential cost associated with manufacture or trafficking of new receptors could be mitigated if pre-existing synaptic AMPARs also undergo a modest conductance change. The literature suggests that the presence of high conductance AMPARs and/or GluA1 homomers confers an unstable synaptic state, suggesting state transitions. An experimental paradigm is proposed to differentiate these possibilitie...Continue Reading

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Citations

Oct 27, 2018·Frontiers in Cellular Neuroscience·Mikyoung Park
Nov 15, 2018·Frontiers in Cellular Neuroscience·Brian G HiesterMatthew J Kennedy
Apr 16, 2020·Frontiers in Synaptic Neuroscience·Alicia M Purkey, Mark L Dell'Acqua
Feb 23, 2021·Frontiers in Synaptic Neuroscience·Motahareh Solina SafariStephanie Zur Nedden
Mar 23, 2021·PLoS Computational Biology·Moritz F P Becker, Christian Tetzlaff
May 29, 2021·Neuropharmacology·Daniel D Cooper, Bruno G Frenguelli
Jul 13, 2021·The European Journal of Neuroscience·Nádia Carolina RodriguesDiana Cunha-Reis
Nov 24, 2021·Neuromolecular Medicine·Ghada YousifYousef Haik

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