PMID: 7513843Feb 14, 1994Paper

AMPA/kainate receptor-mediated damage to NADPH-diaphorase-containing neurons is Ca2+ dependent

Neuroscience Letters
J H WeissD W Choi

Abstract

While exposure times of several hours or more are needed for AMPA or kainate to induce widespread cortical neurodegeneration, the small subset of cortical neurons that contain high concentrations of the enzyme, NADPH-diaphorase (NADPH-d(+) neurons) were destroyed by brief (15-30 min) exposures. AMPA or kainate-induced degeneration of NADPH-d(+) neurons was decreased by removal of extracellular Ca2+ and increased by augmentation of extracellular Ca2+. More than 90% of NADPH-d(+) neurons exhibited kainate-activated Co2+ uptake, suggesting that they possess Ca(2+)-permeable AMPA/kainate receptor-gated channels. The heightened vulnerability of NADPH-d(+) neurons to AMPA or kainate toxicity may reflect rapid Ca2+ entry through these Ca(2+)-permeable channels.

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Citations

Jun 27, 1995·Brain Research. Developmental Brain Research·N J HackR Balázs
Dec 20, 2000·Brain Research·H TanakaR S Zukin
Nov 5, 1997·Trends in Neurosciences·D E Pellegrini-GiampietroR S Zukin
Jun 10, 1998·Cytokine & Growth Factor Reviews·B M Pratt, J M McPherson
Apr 8, 1998·Annual Review of Neuroscience·D W Choi, J Y Koh
Mar 5, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Michaela C PascoeDavid P Crewther
Oct 27, 2005·Journal of Biochemistry and Molecular Biology·Seok Joon WonByoung Joo Gwag
Feb 15, 2001·The Journal of Comparative Neurology·E ZemelI Perlman
Dec 9, 1998·The Journal of Comparative Neurology·C S Toomim, W R Millington
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Doug Lobner
Dec 17, 2020·Frontiers in Molecular Neuroscience·Alberto GranzottoStefano L Sensi

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