Amphetamine analogs methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) differentially affect speech.

Psychopharmacology
Gina F MarroneCarl L Hart

Abstract

Most reports of the effects of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) on speech have been anecdotal. The current study used a within-participant design to assess the effects of methamphetamine and MDMA on speech. Eleven recreational users of amphetamines completed this inpatient, within-participant, double-blind study, during which they received placebo, methamphetamine (20, 40 mg), and MDMA (100 mg) on separate days. Following drug administration, study participants described movies viewed the previous evening and completed mood scales. Methamphetamine increased quantity of speech, fluency, and self-ratings of talkativeness and alertness, while it decreased the average duration of nonjuncture unfilled pauses. MDMA decreased fluency and increased self-ratings of inability to concentrate. To determine if methamphetamine- and MDMA-related effects were perceptible, undergraduates listened to the participants' movie descriptions and rated their coherence and the speaker's mood. Following methamphetamine, descriptions were judged to be more coherent and focused than they were following MDMA. Methamphetamine improved verbal fluency and MDMA adversely affected fluency. This pattern of effects is consistent with t...Continue Reading

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Citations

Nov 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carl L HartEdward E Smith
Feb 3, 2011·Behavior Research Methods·Margaret WardleHarriet de Wit
May 29, 2013·Psychopharmacology·Matthew G Kirkpatrick, Harriet de Wit
Apr 25, 2012·Psychopharmacology·Margaret C WardleHarriet de Wit
Apr 15, 2014·Psychopharmacology·Margaret C Wardle, Harriet de Wit
Nov 7, 2015·BioMed Research International·Débora GonzálezMagí Farré
Apr 8, 2015·The European Journal of Neuroscience·Laura E Matheson, Jon T Sakata
Oct 5, 2014·Psychopharmacology·Matthew G Kirkpatrick, Harriet de Wit
Apr 30, 2015·Journal of Psychopharmacology·Matthew J BaggottHarriet de Wit
Aug 27, 2016·Journal of Psychopharmacology·Anya K BershadHarriet de Wit
Feb 23, 2018·Psychopharmacology·Harriet de Wit, Michael Sayette
Apr 4, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gillinder BediHarriet de Wit
Jan 23, 2019·Journal of Psychopharmacology·Michaela PettieBart A Ellenbroek
Aug 1, 2015·Behavioural Pharmacology·Melissa A MillerHarriet de Wit
Jan 25, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carla AgurtoGillinder Bedi
Jan 16, 2022·Psychopharmacology·Adrian HaseGregor Hasler

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