PMID: 9422363Jan 9, 1998Paper

Amphetamine and D1 dopamine receptor agonists produce biphasic effects on glutamate efflux in rat ventral tegmental area: modification by repeated amphetamine administration

Journal of Neurochemistry
M.E. Wolf, C J Xue

Abstract

Amphetamine or selective D1 and D2 dopamine receptor agonists and antagonists were administered to the ventral tegmental area (VTA) through a microdialysis probe to determine their effects on glutamate and aspartate efflux in rats pretreated for 5 days with vehicle or 5 mg/kg (+)-amphetamine sulfate. In vehicle rats, glutamate efflux declined during 2 h of perfusion with the D1 receptor agonist SKF-82958 (10 and 100 microM). After SKF-82958 perfusion ended, glutamate efflux rebounded to basal levels and continued to increase gradually over the next 2 h. A similar biphasic pattern was observed with intra-VTA amphetamine (10 and 100 microM) and with another D1 agonist (100 microM SKF-38393). The biphasic effects of SKF-82958 were prevented by coperfusion with a D1 antagonist (SCH-23390; 30 microM). Glutamate efflux was unaffected by a D2 agonist (100 microM quinpirole) and by D1 or D2 antagonists administered alone (SCH 23390 and eticlopride; 30 microM). In amphetamine-pretreated rats tested 2 days after the last injection, both the decrease during SKF-82958 perfusion and the delayed increase in glutamate efflux were attenuated. In rats tested 12-14 days after the last amphetamine injection, only the decrease during SKF-82958 per...Continue Reading

Citations

Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karin Magendzo, Gonzalo Bustos
Feb 21, 2006·The European Journal of Neuroscience·Caroline ForgetLouis-Eric Trudeau
Mar 30, 2010·The European Journal of Neuroscience·Leora YetnikoffCecilia Flores
Apr 15, 2011·Pharmacological Reviews·Jeffery D Steketee, Peter W Kalivas
Jun 13, 2018·Frontiers in Psychiatry·Bethania Mongi-BragatoLiliana M Cancela
Mar 15, 2002·Neuroreport·Susan Jones, Johanna L Gutlerner
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nobuyoshi SutoPaul Vezina
Apr 15, 2014·Journal of Drug and Alcohol Research·María E Vélez-HernándezCarlos A Jiménez-Rivera
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Evgeny A BudyginSara R Jones
May 20, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lavina J FaleiroJulie A Kauer
Nov 8, 2020·Neurochemistry International·Kathryn D FischerPaul A Rosenberg
Oct 16, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·P VezinaW N Green
Jun 16, 2009·Biochemical Pharmacology·Phil D Livingstone, Susan Wonnacott

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