Amphetamine exposure is elevated in Parkinson's disease

Neurotoxicology
Elisabeth R GarwoodChadwick W Christine

Abstract

Since the 1930's, amphetamine drugs have been used therapeutically and recreationally. High doses are associated with acute injury to axon terminals of dopaminergic neurons. It is unknown whether low dose exposure to amphetamine over a prolonged time period is associated with the development of Parkinson's disease (PD). A telephone survey of drug and chemical exposure was administered to patients from three faculty practice clinics at UCSF. Patients were asked to participate if they had been diagnosed with peripheral neuropathy (PN), amyotrophic lateral sclerosis (ALS), or PD between the ages of 40 and 64. Spouses or caregivers were also asked to participate. "Amphetamine exposure" was defined as a prior use of amphetamine, methamphetamine or dextroamphetamine. "Prolonged exposure" was defined as amphetamine use that occurred more than twice a week for > or =3 months or weekly usage for > or =1 year and had to occur before diagnosis of the neurological condition. Prolonged exposure to either prescribed or non-prescribed amphetamine was common, occurring in 15% with PN (11/76), 13% with ALS (9/72), and 11% with PD (17/158). Prolonged amphetamine exposure was more frequent in diseased patients compared to spouses when all disease...Continue Reading

References

Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Feb 3, 1999·JAMA : the Journal of the American Medical Association·C M TannerJ W Langston
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Aug 23, 2001·Brain Research. Brain Research Reviews·C DavidsonE H Ellinwood
Feb 7, 2002·Neurotoxicology·T R Guilarte
Jun 14, 2003·Pharmacology & Therapeutics·Jeffrey M Brown, Bryan K Yamamoto
Dec 3, 2003·Brain : a Journal of Neurology·Anna MoszczynskaStephen J Kish
Jul 28, 2004·Neurology·Karin WirdefeldtNancy L Pedersen

❮ Previous
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Citations

Jan 11, 2012·Journal of Neural Transmission·Chadwick W ChristineJill L Ostrem
Mar 17, 2010·AIDS and Behavior·Pria AnandFrederick L Altice
Dec 18, 2013·Annals of Indian Academy of Neurology·Sanjeev V ThomasGeetha Suresh
Mar 31, 2010·Stem Cell Reviews and Reports·Liang XuSheng-Di Chen
May 22, 2013·The Psychiatric Clinics of North America·Daniel E Rusyniak
Jun 19, 2012·Experimental Neurology·John R Sladek
Aug 2, 2011·Neurologic Clinics·Daniel E Rusyniak
Oct 13, 2015·Progress in Neurobiology·Rosario MoratallaMicaela Morelli
May 12, 2009·Addiction·Christopher C Cruickshank, Kyle R Dyer
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Simon ZhornitskyStéphane Potvin
Aug 26, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Russell C CallaghanStephen J Kish
Jan 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Chadwick W ChristineCharles E McCulloch
Oct 11, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Giulia CostaMicaela Morelli
Mar 27, 2015·Parkinson's Disease·Philippe HuotJonathan M Brotchie
Jun 21, 2017·The Journal of Pharmacology and Experimental Therapeutics·Anna Moszczynska, Sean Patrick Callan
Jun 18, 2020·Life·Carla FerreiraAlexandre Quintas
Sep 11, 2018·Frontiers in Cellular Neuroscience·Lin-Nan ZhuPing-Ming Qiu
Sep 14, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen CurtinGlen R Hanson
Apr 4, 2019·Frontiers in Neurology·Nicole BallJames Chapman
Jul 1, 2017·The European Journal of Neuroscience·Amanda FlackAnna Moszczynska
May 10, 2020·The Journal of Pharmacology and Experimental Therapeutics·Charlotte P MageeAnnette E Fleckenstein
Feb 9, 2021·Neurotoxicity Research·Manqing WuMin Zhao
Feb 10, 2021·Harvard Review of Psychiatry·Alan A Baumeister
Jun 30, 2021·Experimental Neurology·Subramaniam JayanthiJean Lud Cadet
Jul 24, 2021·Experimental Neurology·Akhil SharmaAnna Moszczynska
Jul 29, 2021·Journal of Neurochemistry·Charlotte P MageeAnnette E Fleckenstein
Oct 6, 2021·Molecular Neurobiology·Ángel Juan García-YagüeAntonio Cuadrado

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