Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function

Brain Research
Sheryl S MoyGary E Duncan

Abstract

Genetically altered mice with reductions in the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor have been proposed as a model for the intrinsic NMDA hypofunction hypothesized for schizophrenia. The following study investigated whether NR1-deficient mice have enhanced susceptibility for the effects of amphetamine, similar to the exaggerated responsivity to dopamine agonists observed in many schizophrenia patients. NR1-/- mice and wild-type controls were tested for the effects of amphetamine (2-10 mg/kg) on prepulse inhibition of acoustic startle responses. The results showed that mice with reduced NMDA receptor function demonstrated consistent deficits in prepulse inhibition (PPI), as well as higher startle response amplitudes. In comparison to normal controls, the NR1-/- mice were more sensitive to the disruptive effects of amphetamine on PPI, but not to the drug effects on startle magnitude without a prepulse stimulus. Wild-type mice only showed decreased PPI at the highest dose of amphetamine tested (10 mg/kg) and demonstrated small increases in PPI at lower amphetamine doses (2 and 6 mg/kg). The NR1-/- mice did not show enhanced PPI in response to amphetamine at low doses, with reductions in PPI apparent at doses of ...Continue Reading

References

Dec 1, 1976·Archives of General Psychiatry·C Kornetsky
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Jan 1, 1990·Schizophrenia Bulletin·T W Robbins
Jan 1, 1987·Psychopharmacology·J A LiebermanJ Alvir
Sep 1, 1988·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S H Snyder
Jan 1, 1988·Psychopharmacology·R S MansbachD L Braff
Feb 1, 1973·Archives of General Psychiatry·D S JanowskyH J Sekerke
Dec 1, 1995·Archives of General Psychiatry·J W Olney, N B Farber
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·N R Swerdlow, M A Geyer
Aug 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A C LahtiC A Tamminga
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M LaruelleR B Innis
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BreierD Pickar
Jul 1, 1997·Psychopharmacology·R Paylor, J N Crawley
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A K MalhotraA Breier
Jan 28, 1998·Critical Reviews in Neurobiology·C A Tamminga
Mar 4, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D Jentsch, R H Roth
Jun 15, 1999·Psychopharmacology·K E Hutchison, R Swift
Oct 20, 1999·Psychopharmacology·N R SwerdlowD L Braff
Jan 11, 2000·Journal of Psychiatric Research·J W OlneyN B Farber
Mar 17, 2000·Brain Research. Brain Research Reviews·A CarlssonM L Carlsson
Apr 4, 2000·Biological Psychiatry·A ParwaniJ P Rotrosen
Jun 27, 2000·Schizophrenia Research·J Addington, D Addington
May 22, 2002·Psychopharmacology·Sheryl S Moy, George R Breese
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neal R SwerdlowPamela P Auerbach
Mar 1, 1959·A.M.A. Archives of Neurology and Psychiatry·E D LUBYR KELLEY
Jul 1, 1962·The American Journal of Psychiatry·E D LUBYE F DOMINO
Oct 7, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Seiya MiyamotoGary E Duncan
Oct 8, 2004·Schizophrenia Research·Veena KumariTonmoy Sharma
Apr 12, 2005·Biological Psychiatry·David L BraffNeal R Swerdlow
Jun 14, 2005·Schizophrenia Research·Marcia Voges, Jean Addington
Jul 28, 2005·Behavioural Brain Research·Rosa L FradleyDavid S Reynolds

❮ Previous
Next ❯

Citations

Sep 25, 2010·Psychopharmacology·Michael A BenneyworthJoseph T Coyle
Nov 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Monica Beneyto, James H Meador-Woodruff
Jul 1, 2009·Genes, Brain, and Behavior·T B HaleneS J Siegel
Feb 4, 2012·Genes, Brain, and Behavior·C BarkusD M Bannerman
Jun 26, 2012·Genes, Brain, and Behavior·M J GandalS J Siegel
May 11, 2012·Developmental Neuroscience·Sheryl S MoyBeverly H Koller
Feb 4, 2016·Acta Biochimica Et Biophysica Sinica·Peijun Ju, Donghong Cui
Aug 22, 2009·Neuroscience and Biobehavioral Reviews·Viviane Labrie, John C Roder
Jun 23, 2009·Behavioural Brain Research·Sheryl S MoyPatricia F Maness
Jun 2, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tatsuya KotakaShigetoshi Kuroda
May 5, 2009·Pharmacology, Biochemistry, and Behavior·Leon G ColemanFulton T Crews
Dec 11, 2007·Behavioural Brain Research·Sheryl S MoyJames W Bodfish
Aug 3, 2007·Pharmacology, Biochemistry, and Behavior·Amanda K AndrusJacques P J Maurissen
Feb 12, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Holly R Robertson, Guoping Feng
Nov 12, 2013·Behavioural Brain Research·Sheryl S MoyJames W Bodfish
Nov 16, 2017·The European Journal of Neuroscience·Tomonori FujiwaraKimio Akagawa
Jan 11, 2007·Genes, Brain, and Behavior·J B Panksepp, G P Lahvis
Jun 26, 2020·Annals of Neurology·Marc Carceles-CordonJosep Dalmau
Aug 17, 2019·Frontiers in Molecular Neuroscience·Gloria Lee, Yi Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.