Amphetamine-induced hyperactivity: differences between rats with high or low preference for alcohol

Alcohol
C FahlkeS Hansen

Abstract

This study determined the relationship between ethanol intake and spontaneous and amphetamine-induced locomotor activity. Locomotion was studied in high-preferring (HP; > 70% of total fluid intake consumed as alcohol) and low-preferring (LP; < 20% of total fluid intake consumed as alcohol) male Wistar rats with free access to water and a 6% (v/v) ethanol solution for 3 weeks. Following an alcohol-free 3-week period, the animals were tested for spontaneous motor activity for 1 h. One week later, locomotion was recorded in the same activity boxes following a subcutaneous injection with d-amphetamine sulfate (1 mg/kg). For determination of plasma levels of corticosterone, blood samples were taken immediately after each of the two tests for locomotor activity. There was no difference between HP and LP rats with regard to spontaneous locomotor activity. Neither were there any differences in plasma levels of corticosterone between the groups. Amphetamine stimulated locomotion in both HP and LP rats, but to a significantly greater extent in HP animals. Both groups had higher blood levels of corticosterone after the amphetamine test than after the drug-free test, but the corticosterone increase was significantly larger in the HP than i...Continue Reading

References

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Citations

Dec 22, 2000·Pharmacology, Biochemistry, and Behavior·P JohanssonC Fahlke
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·D L McKinzieT-K Li
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·M MiquelC M Aragòn
Oct 18, 2002·The European Journal of Neuroscience·Tamzin L RipleyDavid N Stephens
May 1, 2001·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
Dec 17, 2011·Brain Research Bulletin·Thomas I NathanielJaak Panksepp
Oct 19, 2011·Alcoholism, Clinical and Experimental Research·Scott J HaytonMary C Olmstead
Dec 18, 2012·Alcoholism, Clinical and Experimental Research·Kenneth J D Allen, Frances H Gabbay
Jan 31, 2012·Pharmacology, Biochemistry, and Behavior·Larissa A Pohorecky, April Sweeny
Mar 13, 2015·Psychopharmacology·Yann PellouxDominique Duterte-Boucher
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Sònia DarbraNuria Ferré

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