Amphetamine-induced rapid-onset sensitization: role of novelty, conditioning and behavioral parameters

Pharmacology, Biochemistry, and Behavior
Juliana do Nascimento AlvarezRoberto Frussa-Filho

Abstract

Environmental factors may modulate sensitization to the locomotor-activating effects of psychostimulants. In addition, some parameters of locomotor activity seem to be more sensitive to detect cocaine-induced behavioral sensitization. We examined how novelty and conditioning can modulate a previously described rapid-onset type of behavioral sensitization to amphetamine (AMP) in mice, using total, peripheral and central open-field locomotion frequencies as experimental parameters. In the first experiment, mice received an ip injection of saline (SAL) or 5.0 mg/kg AMP paired or not with the open-field or in their home-cages. Four hours later, all the animals received an ip SAL challenge injection and, 15 min later, were observed in the open-field for quantification of total, peripheral and central locomotion frequencies. The second experiment had a similar protocol, except that mice received a challenge injection of 1.5 mg/kg AMP. The priming AMP injection significantly increased all the parameters of locomotion of SAL-challenged mice firstly exposed to or previously paired (but not unpaired) with the open-field. AMP priming injection enhanced total and peripheral locomotion of all AMP-challenged mice but only increased central l...Continue Reading

Citations

Dec 9, 2009·Pharmacology, Biochemistry, and Behavior·Daniela F FukushiroRoberto Frussa-Filho
Aug 19, 2008·Neurobiology of Learning and Memory·Tathiana A AlvarengaSergio Tufik
Sep 2, 2008·Physiology & Behavior·Nilza Pereira de AraujoRoberto Frussa-Filho
Aug 30, 2008·Brain Research Bulletin·Daniela Fukue FukushiroRoberto Frussa-Filho
Sep 28, 2015·Neurotoxicology and Teratology·Julia Z MagalhãesHelenice S Spinosa
Jul 17, 2007·Physiology & Behavior·Daniela Fukue FukushiroRoberto Frussa-Filho
May 20, 2014·Pharmacology, Biochemistry, and Behavior·L F BerroR Frussa-Filho
Jun 19, 2013·Journal of Neuroscience Methods·Elsbeth A van DamLucas P J J Noldus
May 21, 2011·Drug and Alcohol Dependence·Roberta Procópio-SouzaRoberto Frussa-Filho
Feb 1, 2011·Pharmacology, Biochemistry, and Behavior·Sonia R KamedaRoberto Frussa-Filho
Dec 10, 2013·Pharmacology, Biochemistry, and Behavior·Luis P SaitoRoberto Frussa-Filho
Jun 22, 2012·The International Journal of Neuropsychopharmacology·Leandro SandayRoberto Frussa-Filho
Dec 16, 2010·The International Journal of Neuropsychopharmacology·Daniela F Fukushiro, Roberto Frussa-Filho
Oct 15, 2019·The Journal of Pharmacy and Pharmacology·Victor Celso Cavalcanti CapibaribeFrancisca Cléa Florenço de Sousa

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