Mar 17, 2004

Amphetamine neurotoxicity: accomplishments and remaining challenges

Neuroscience and Biobehavioral Reviews
Una McCann, George Ricaurte

Abstract

In addition to the social, cultural and indirect medical complications of amphetamine analog abuse, this class of drugs is also known to have the potential to damage brain monoaminergic cells directly. Using methamphetamine as a prototype, this article provides a brief review of the history of amphetamine neurotoxicity research and the progress that has been made toward defining its characteristics. Remaining challenges for this line of investigation are outlined, and suggested avenues for addressing these challenges are provided.

Mentioned in this Paper

Presynaptic Terminals
Amphetamine
Alpha-Neurotoxins
Neurons
Serotonin
Thyramine
Brain
Analog
Uptake
Neuroprotection

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