Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family.

Journal of Molecular Evolution
D N HaefligerW Wahli

Abstract

The Xenopus laevis 68-kd and 74-kd albumin amino acid sequences are examined with respect to their relationship to the other known members of the albumin/alpha-fetoprotein/vitamin D-binding protein gene family. Each of the three members of this family presents a unique pattern of conserved regions indicating a differential selective pressure related to specific functional characteristics. Furthermore, an evolutionary tree of these genes was deduced from the divergence times calculated from direct nucleotide sequence comparisons of individual gene pairs. These calculations indicate that the vitamin D-binding protein/albumin separation occurred 560-600 million years (Myr) ago and the albumin/alpha-fetoprotein divergence 280 Myr ago. This observation leads to the hypothesis according to which the albumin/alpha-fetoprotein gene duplication occurred shortly after the amphibian/reptile separation. Consequently, and unlike mammals, amphibians and fishes should lack an alpha-fetoprotein in their serum at larval stages, which is consistent with a recent analysis of serum proteins in Xenopus laevis larvae. This hypothesis now will have to be tested further in additional lower vertebrates.

References

Feb 25, 1977·Science·C A BisbeeM Fischberg
Jan 1, 1977·Annual Review of Biochemistry·A C WilsonT J White
Feb 20, 1975·Nature·M GoodmanG Matsuda
Dec 1, 1986·Biochemical Genetics·J D Graf, M Fischberg
Aug 1, 1974·Differentiation; Research in Biological Diversity·J LindgrenE Ruoslahti
Mar 1, 1970·Journal of Molecular Biology·S B Needleman, C D Wunsch
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L L JagodzinskiJ Bonner
Aug 11, 1981·Nucleic Acids Research·B WestleyR Weber
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R S IngramS M Tilghman
Nov 25, 1981·Nucleic Acids Research·R M LawnK L Wion
Jan 11, 1982·Nucleic Acids Research·M I Kanehisa
Dec 21, 1981·Nucleic Acids Research·D R Schoenberg
Jan 1, 1982·Differentiation; Research in Biological Diversity·B Westley, R Weber
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T MorinagaT Tamaoki
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A DugaiczykO E Dennison
Aug 5, 1983·Journal of Molecular Biology·F E MayR Weber
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J Wilbur, D J Lipman
Oct 1, 1980·Cell·A EfstratiadisN J Proudfoot
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T D SargentJ Bonner
Jun 1, 1980·Cell·F PerlerJ Dodgson
Sep 1, 1978·Wilhelm Roux's Archives of Developmental Biology·Walter WahliRudolf Weber

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Citations

Feb 1, 1992·Protein Science : a Publication of the Protein Society·J E Gray, R F Doolittle
Feb 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·X J GuanS M Tilghman
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·B PandjaitanS Spitzauer
Jan 24, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M A BrownP Licht
Feb 11, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J L Hunt, P Licht
Dec 20, 2002·Mechanisms of Development·Elke A OberDidier Y R Stainier
Sep 21, 2000·Trends in Endocrinology and Metabolism : TEM·P White, N Cooke
Apr 25, 1990·Nucleic Acids Research·J E MoskaitisD R Schoenberg
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Joris R DelangheMarijn M Speeckaert
May 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edmondo FalletiPierluigi Toniutto
May 16, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marijn SpeeckaertYouri E C Taes
Aug 25, 2011·Journal of the Neurological Sciences·Joost SmoldersTrygve Holmøy
Jul 7, 2017·Evolutionary Bioinformatics Online·Shugang LiFang Geng
Jul 1, 1993·European Journal of Biochemistry·J X HoD C Carter
Apr 25, 2012·Cell Biochemistry and Function·Rene F Chun
Jun 13, 2012·Alimentary Pharmacology & Therapeutics·M GargP R Gibson
Sep 26, 2013·International Journal of Molecular Medicine·Jin-Hee HwangHong-Gu Lee
May 25, 2005·Proteomics·Jonathan E MangumMichael J Hubbard

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