Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo

Bioorganic & Medicinal Chemistry Letters
Deyue YanChien-Chung Cheng

Abstract

Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol-norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.

References

Jun 21, 2001·Journal of Agricultural and Food Chemistry·S Burda, W Oleszek
Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Sep 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Srinivasan RamachandranRatnesh Lal
May 15, 2012·Journal of Agricultural and Food Chemistry·Francisco A Tomás-Barberán, Cristina Andrés-Lacueva
Jul 11, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Rachel M LevineEfrosini Kokkoli

❮ Previous
Next ❯

Citations

Feb 12, 2020·Future Microbiology·Kaila P Medina-AlarcónAna M Fusco-Almeida
Sep 7, 2018·Experimental and Therapeutic Medicine·Jing ZhuWei Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

British Medical Journal
C R PENGELLY
Progress in Clinical and Biological Research
R Anton
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Mingliang FanBizhi Shi
© 2022 Meta ULC. All rights reserved