Amphiphilic polyelectrolyte/prodrug nanoparticles constructed by synergetic electrostatic and hydrophobic interactions with cooperative pH-sensitivity for controlled doxorubicin delivery

ACS Applied Materials & Interfaces
Pingsheng HuangJianhua Zhang

Abstract

To achieve higher therapeutic efficiency with catabatic side effects, desirable nanocarriers should be designed to retain the loaded drug tightly during the systemic circulation, but release the drug rapidly and efficiently upon endocytosis by tumor cells. Herein, to achieve "off-on" controlled delivery of DOX, novel amphiphilic polyelectrolyte/prodrug nanoparticles (NPs) with cooperative pH-sensitivity were constructed via synergistic electrostatic and hydrophobic interactions between slightly positively charged methoxy polyethylene glycol-b-(poly(2-(diisopropylamino) ethyl methacrylate-co-aminopropyl methacrylamide) (PEDPA) copolymer and negatively charged cis-aconityl-doxorubicin (CAD) prodrug (termed as PEDPA/CAD NPs). With polymer-prodrug synergistic noncovalent interactions, the drug loading content of PEDPA/CAD NPs could be improved up to 12.6% with favorable serum stability, and significantly lowered the drug leakage to 2.5% within 24 h at pH 7.4. However, nearly 80% of encapsulated drug could be released at pH 5.0 within 12 h, due to the cooperative effects of the protonation of PDPA blocks resulting in quick disassembly of NPs and the rapid hydrolysis of cis-aconityl linkage leading to charge-reverse of CAD. Moreover,...Continue Reading

References

Feb 1, 1995·Pharmaceutical Research·G S KwonK Kataoka
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H S Yoo, T G Park
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang YooTae Gwan Park
May 17, 2003·Nature Reviews. Drug Discovery·Ruth Duncan
Oct 29, 2004·Nature Reviews. Cancer·Carl-Henrik HeldinArne Ostman
Jul 17, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y TianKam C Tam
Sep 27, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Allan S Hoffman
Jun 25, 2009·Current Medicinal Chemistry·Cristina CarvalhoPaula I Moreira
Dec 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ranjita Misra, Sanjeeb K Sahoo
Aug 14, 2010·Biomaterials·Sung Ho KimJames L Hedrick
Mar 2, 2011·Molecules and Cells·Ki Hyun BaeTae Gwan Park
Mar 26, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuxuan ZhuXiaohui Li
Jun 23, 2011·Accounts of Chemical Research·Jinjun ShiOmid C Farokhzad
Oct 5, 2011·ACS Nano·Ki Young ChoiJae Hyung Park
Jan 27, 2012·Journal of Medicinal Chemistry·Bhupender S ChhikaraKeykavous Parang
Jun 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zibin GaoYongjun Sun
Dec 18, 2012·Nano Today·Joseph W Nichols, You Han Bae
Jun 15, 2013·Chemical Society Reviews·Jiaming ZhuangS Thayumanavan
Jun 29, 2013·Journal of Biomaterials Science. Polymer Edition·Longlong ChangAnjie Dong
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Jan 31, 2014·Biomaterials·Stephen W MortonPaula T Hammond
Jul 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pingsheng HuangAnjie Dong

❮ Previous
Next ❯

Citations

Feb 3, 2016·ACS Applied Materials & Interfaces·Qiang ChengZicai Liang
Nov 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pingsheng HuangAnjie Dong
Oct 31, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Liandong DengJianhua Zhang
Aug 3, 2016·ACS Applied Materials & Interfaces·Yangjun ChenQiao Jin
Jan 9, 2016·Experimental Biology and Medicine·Ying ZhangYong Sun
Dec 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sonja DragojevicDrazen Raucher
Dec 29, 2017·Nanomaterials·Fuli ZhaoJianhua Zhang
Aug 15, 2017·Journal of Drug Targeting·Juan LiRongmei Wang
Sep 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tuanwei LiuXinlin Yang
Sep 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoxiao ShiZhigang Xu
Feb 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi Y WangYue Wang
Nov 13, 2018·Colloid and Polymer Science·Xiaoting ZhangXiaoze Jiang
Dec 27, 2018·International Journal of Pharmaceutics·Shukai DingThierry F Vandamme
Jan 14, 2019·ACS Biomaterials Science & Engineering·Chetan NehateVeena Koul
May 2, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Jing ZhangShiyong Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.