Amphiphilic prodrug-decorated graphene oxide as a multi-functional drug delivery system for efficient cancer therapy

Materials Science & Engineering. C, Materials for Biological Applications
Chunzhi HuangYuxia Luan

Abstract

Graphene oxide (GO) has shown great potential in drug delivery. However, the aqueous stability, non-specific drug release and slow release rate are major problems of the GO-based drug delivery system. Herein, we for the first time integrate the dispersant, stabilizing agent and active targeting carrier into a novel drug delivery system based on GO/PP-SS-DOX nanohybrids. The redox-sensitive PP-SS-DOX prodrug was obtained by conjugating mPEG-PLGA (PP) with doxorubicin (DOX) via disulfide bond. PEG-FA provided active targeting property for the constructed drug delivery system, GO/PP-SS-DOX/PEG-FA. In this demonstrated system, PP-SS-DOX markedly increases the stability in physiological solutions of GO and guarantees the DOX release in the reductive environment (cancerous cells). And PEG-FA helps target to cancerous tissues and induces FR-mediated endocytosis. In vitro drug release exhibited the obvious reductive sensitivity and the cumulative release amount was up to 90%, while 40% in previous reports within 72 h. The in vitro cytotoxicity of targeting nanohybrids was significantly cytotoxic than that of non-targeting nanohybrids. In vivo results displayed that the as-prepared targeting nanohybrids showed efficacious antitumor effe...Continue Reading

Citations

Dec 15, 2019·Nanomaterials·Daniela Plachá, Josef Jampilek
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shirin MollazadehMostafa Yazdimamaghani
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicolò MauroGennara Cavallaro
Apr 16, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Jing ZhangJie Feng
Jan 6, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Rahul PatilSanjay Tiwari
Nov 15, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Ali PourjavadiMehdi Akhlaghi

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