Amphiphilic Triblock Copolymer Prodrug for Tumor-Specific pH/Reduction Dual-Triggered Drug Delivery: Effect of Self-Assembly Behaviors.

Langmuir : the ACS Journal of Surfaces and Colloids
Yuman Dong, Peng Liu

Abstract

Diblock copolymer-based prodrugs have been widely designed for tumor treatment after self-assembly; however, premature drug leakage could not be ignored because their hydrophobic prodrug cores were directly exposed to the media. Here, an amphiphilic triblock copolymer prodrug with a hydrophilic PEG block, a pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) block, and a hydrophobic reduction-cleavable prodrug block was synthesized for tumor-specific pH/reduction dual-triggered drug delivery, via the successive RAFT polymerization of DPA and a DOX-based monomer (MAL-DOX) with a PEG-based macro-CTA. The core-shell and core-shell-corona nanoparticles could be obtained by one-step and two-step self-assembly. With the pH-sensitive gatekeeper formed by the PDPA block, the core-shell-corona nanoparticles possessed a smaller diameter with narrow distribution and better drug release with lower drug leakage. MTT assays demonstrated the selective cytotoxicity of the core-shell-corona nanoparticles to the cancer cells was dose-dependent because of the reduction-cleavable prodrug. The negligible drug leakage and selective cytotoxicity to cancer cells endow the proposed core-shell-corona prodrug nanoparticles with promising pot...Continue Reading

References

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Jun 2, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Xiangxuan HuangCan Yang Zhang
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Huifang Zhang, Peng Liu
Aug 28, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Debabrata DuttaZhishen Ge
Aug 30, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuman DongPeng Liu
Dec 10, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Haiyan SuiJiwei Cui
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Sep 30, 2020·Colloids and Surfaces. B, Biointerfaces·Yuman Dong, Peng Liu

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