Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Michiyo YamadaHiroshi Shimada

Abstract

Aberrant activation of epidermal growth factor receptors (EGFR/HER1) by ligand stimulation or heterodimerization with human epidermal growth factor 2 (HER2) is considered to play an important role in the development of colorectal carcinoma. Amphiregulin (AR) is a ligand of EGFR that might be related to the development and progression of gastrointestinal tumors. The aim of this study was to determine the AR, EGFR, and HER2 protein expression levels and to evaluate their prognostic relevance to the clinical course of colorectal cancer. The AR, EGFR, and HER2 protein levels in primary tumors of colorectal cancer (n = 106) were examined using immunohistochemistry. Metastatic sites in liver specimens (n = 16) were also analyzed in the same manner. Thirteen (81.6%) metastatic lesions of the liver stained positive for AR. Among the primary lesions of colorectal cancer, 58 (54.7%) stained positive for AR, 13 (12.3%) stained positive for EGFR, and 5 (4.7%) stained positive for HER2. When the relationships between each protein expression level and the clinicopathologic factors were examined, only the AR expression level was significantly related to liver metastasis (P = 0.0296). A multivariate analysis of liver metastasis proved that AR ...Continue Reading

References

Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F CiardielloD S Salomon
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Dec 1, 1990·The British Journal of Surgery·R J SteeleO Eremin
Aug 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C H FoxP P Roller
Oct 4, 1984·Nature·J DownwardM D Waterfield
Jul 3, 1998·International Journal of Cancer. Journal International Du Cancer·I ZvibelM Papa
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T W JacobsS J Schnitt
Oct 8, 2003·Diseases of the Colon and Rectum·Reinhard KoppAndreas Pfeiffer
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzRobert J Mayer
Jun 23, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Derek AtkinsStephan Störkel
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Feb 3, 2005·Gastroenterology·Carmen BerasainMatías A Avila
Feb 3, 2005·Gastroenterology·George K Michalopoulos, Zahida Khan
Feb 4, 2005·The New England Journal of Medicine·Jeffrey A Meyerhardt, Robert J Mayer
Mar 9, 2005·The Journal of Biological Chemistry·Carmen BerasainMatías A Avila
Jun 28, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A ItalianoJ-F Michiels

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Citations

Oct 15, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ming-Hung TsaiJau-Song Yu
Oct 12, 2012·Clinical & Experimental Metastasis·Harold J WaneboNancey E Kemeny
Dec 25, 2012·Journal of Gastrointestinal Cancer·Michael J GuzmanHongmiao Sheng
Jan 28, 2014·Seminars in Cell & Developmental Biology·Carmen Berasain, Matías A Avila
Nov 5, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kaidi MikhitarianChanjuan Shi
Jun 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Toshiaki WatanabeHirokazu Nagawa
Dec 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alphonse E SiricaJennifer L Dewitt
Dec 18, 2010·Journal of Surgical Oncology·Mark P LeGolvan, Murray Resnick
May 21, 2011·The Journal of Pathology·Amandine HurbinElisabeth Brambilla
Jun 11, 2011·Biochimica Et Biophysica Acta·Benoit BusserAmandine Hurbin
Feb 25, 2009·Expert Opinion on Therapeutic Targets·Serena MarchiòRenata Pasqualini
Oct 27, 2018·EMBO Molecular Medicine·Markus LinderMaria Sibilia
Jul 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ya-Ling HsuPo-Lin Kuo
Sep 6, 2019·International Journal of Oncology·Ming-Ju HsiehJui-Chieh Chen
Apr 11, 2018·FEBS Open Bio·Vishnu HosurMichael V Wiles
Aug 30, 2016·World Journal of Gastroenterology : WJG·Mitsuro Kanda, Yasuhiro Kodera
Nov 4, 2020·Cancers·Aintzane ApraizBeatriz Arteta
Apr 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazuo YasumotoSeiji Yano
Oct 27, 2021·Journal of Cellular Physiology·Siddharth S SinghRajiv Kumar

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