Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus

Molecular Endocrinology
S K DasS K Dey

Abstract

A synchrony between the activated state of the blastocyst and differentiation of the uterus to the receptive state is essential to the process of implantation. This process is directed by progesterone (P4) and estrogen. The mechanism by which P4 differentiates the uterus, enabling estrogen to initiate implantation, is unknown but likely to involve localized induction of growth and differentiation factors. We have cloned the murine amphiregulin (AR) gene, a newly discovered member of the epidermal growth factor family, and demonstrate that its expression is implantation-specific and P4-regulated in the mouse uterus. A transient surge in AR mRNA levels occurred throughout the uterine epithelium on day 4 of pregnancy. With the onset of blastocyst attachment late on day 4, AR mRNA accumulated in the luminal epithelium exclusively at the sites of blastocysts. Thus, AR expression correlated first with rising P4 levels and then with the attachment reaction. The rapid induction of AR mRNA in the ovariectomized uterus only by P4 and abrogation of this induction by RU-486 (a P4 receptor antagonist) suggest that this uterine gene is regulated by P4. AR appeared to exhibit preferential phosphorylation of epidermal growth factor receptor in...Continue Reading

Citations

Sep 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanne TranguchSudhansu K Dey
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wen-ge MaSudhansu K Dey
Nov 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Huirong XieSudhansu K Dey
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S K DasD B Lubahn
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S W CurtisK S Korach
Dec 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heather L FrancoFrancesco J Demayo
Jun 16, 2007·The Journal of Clinical Investigation·Susanne TranguchSudhansu K Dey
Aug 9, 2008·Endocrinology·Rodrigo Fernandez-ValdiviaJohn P Lydon
Jun 25, 2009·Endocrinology·John P Lydon, Dean P Edwards
Mar 15, 2008·Endocrinology·Jemma EvansHenry N Jabbour
Feb 7, 2009·Seminars in Reproductive Medicine·Ozlem Guzeloglu-KayisliHugh S Taylor
May 28, 2013·Breast Cancer Research : BCR·Mark D AupperleeSandra Z Haslam
Apr 26, 2008·Journal of Mammary Gland Biology and Neoplasia·Nicole E Willmarth, Stephen P Ethier
Mar 29, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hanwang Zhang, Qiaohong Lai
Aug 9, 2011·Molecular and Cellular Endocrinology·Michael J Large, Francesco J DeMayo
Mar 5, 2016·Biochemical and Biophysical Research Communications·Sijeong BaeYoungsok Choi
Dec 22, 2015·Cell and Tissue Research·Kazuki YamagamiNobuhiko Yamauchi
May 20, 2015·The Journal of Reproduction and Development·Ján BurkušŠtefan Čikoš
Mar 11, 2015·Veterinary Research Communications·Emel AlanHakan Sağsöz
Sep 18, 2015·PLoS Genetics·Tae Hoon KimJae-Wook Jeong
Oct 15, 2005·Experimental Cell Research·Carley N SauterMichael K Fritsch
Feb 26, 2008·Cytokine & Growth Factor Reviews·Marlon R Schneider, Eckhard Wolf
Jan 28, 2014·Seminars in Cell & Developmental Biology·Carmen Berasain, Matías A Avila
Nov 27, 2008·Reproduction in Domestic Animals = Zuchthygiene·Y-J KimE-B Jeung
Sep 2, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D D CarsonE G Regisford
Sep 29, 2017·Cell and Tissue Research·Md Rashedul IslamNobuhiko Yamauchi

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