Abstract
Amphotericin B (AmB) has been able to lengthen the incubation period of intracerebrally (ic) scrapie-injected hamsters to 45 d. This article reports a linear relationship between AmB doses and the duration of the incubation periods of ic-treated animals compared with controls, a greater effect of AmB treatment administered 2 w before or the same day of ic scrapie incubation, and the ineffectiveness of mepartricin, an AmB analogue, in prolonging the incubation period of ic scrapie-injected hamsters. The beneficial effect of AmB appears due to a delay in the replication of the scrapie agent in the brain of infected hamsters. Moreover, AmB suppresses scrapie replication in the spleen of treated animals. Three hypotheses may explain these results: (1) AmB alters a hypothetical scrapie receptor, preventing the entry of the agent into central nervous system (CNS) target cells; (2) AmB interferes with mechanisms involved in scrapie replication; (3) AmB prevents the formation and accumulation of a scrapie-specific amyloid protein responsible for the disease. Whatever the mechanism of action, AmB is the only currently available drug to modify experimental CNS scrapie infection, so AmB is proposed as a novel class of antiscrapie drugs.
Citations
Sep 1, 1991·European Journal of Epidemiology·M PocchiariC Masullo
Jan 1, 1989·Archives of Virology·P CasacciaM Pocchiari
Jan 1, 1994·Molecular Aspects of Medicine·M Pocchiari
Jul 1, 1996·Research in Virology·K T AdjouD Dormont
Sep 21, 2000·Mechanisms of Ageing and Development·W E MüllerH C Schröder
Mar 1, 1992·The Journal of General Virology·A LadoganaM Pocchiari
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·P CasacciaA Cittadini
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·K T AdjouD Dormont
May 24, 2000·Journal of Virology·V BeringueD Dormont
Jun 17, 2006·BMC Veterinary Research·Loredana IngrossoMaurizio Pocchiari
Jan 11, 2000·Journal of Comparative Pathology·K T AdjouD Dormont
Apr 4, 2012·Expert Opinion on Drug Discovery·Federico BenettiGiuseppe Legname
Feb 1, 2010·Expert Opinion on Drug Discovery·Federico BenettiGiuseppe Legname
Apr 1, 1997·Expert Opinion on Investigational Drugs·V BeringueD Dormont
Apr 6, 2006·Transfusion·Vito Angelo BerardiMaurizio Pocchiari
Nov 16, 2011·Transfusion·Franco CardoneMaurizio Pocchiari
Feb 1, 1993·Medical Hypotheses·U Agrimi, G Di Guardo
May 8, 2003·Clinics in Laboratory Medicine·Giacomina RossiFabrizio Tagliavini
Oct 3, 2003·British Medical Bulletin·Dominique Dormont
Feb 24, 2001·Nature·C Thompson
Apr 16, 1992·Nature·Y G XiM Pocchiari
Jul 23, 2019·PloS One·Heather BenderMark Zabel
Dec 2, 1999·The Journal of General Virology·L IngrossoM Pocchiari
Nov 5, 1997·Experimental Neurology·S PerovicW E Müller
Jan 1, 1995·Journal of Virology·L IngrossoM Pocchiari
Feb 1, 1996·Journal of Virology·C I LasmézasD Dormont
Nov 1, 1994·Journal of Virology·D McKenzieJ Aiken
Nov 26, 1997·Journal of Virology·R DemaimayD Dormont