PMID: 9425363Jan 13, 1998Paper

Amphotericin B is superior to sodium antimony gluconate in the treatment of Indian post-kala-azar dermal leishmaniasis

Annals of Tropical Medicine and Parasitology
C P ThakurA Kumar

Abstract

Parasitologically confirmed cases of post-kala-azar dermal leishmaniasis (PKDL) were treated by infusion with amphotericin B deoxycholate (ABD; 1 mg/kg.day on days 1-20, 21-40 and 61-80) or by intramuscular injection with sodium antimony gluconate (SAG; 20-day courses at 20 mg/kg day, with 20-day, drug-free intervals). Of the 11 patients given ABD, all were cured with the three courses, none relapsed in 12 months of follow-up, all developed mild adverse effects (shivering and fever) because of the infusion, five lost their appetites, and three showed increases in their serum creatinine concentrations (although none exceeded 'normal' limits). In contrast, only seven (63%) of the 11 patients given SAG were considered treatment successes (improvement in lesions by the end of the third course) and these took six courses (two cases), nine courses (four cases) or 10 courses (one case) to cure completely. Two of the patients given SAG developed arthralgia and two others developed non-specific ST changes in their electrocardiograms (ECG), although their ECG were normal between courses. The better cure rate with ABD was not statistically significant, probably because of the small sample size. However, ABD appears to be a superior to SAG...Continue Reading

Citations

May 1, 2008·The Journal of Infectious Diseases·Sudipto GangulyMitali Chatterjee
Dec 1, 2011·International Journal of Dermatology·Sarman SinghJyotsna Mishra
Dec 2, 2005·Expert Opinion on Pharmacotherapy·Shyam Sundar, Madhukar Rai
Dec 6, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Shyam SundarVikram Singh
May 31, 2014·Journal of Tropical Medicine·Shyam SundarOm Prakash Singh
May 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·E E Zijlstra, A M el-Hassan
Feb 4, 2005·International Journal of Dermatology·Ali NikzadYahya Dowlati
Dec 22, 2012·Expert Opinion on Pharmacotherapy·Shyam Sundar, Jaya Chakravarty
Feb 17, 2015·TheScientificWorldJournal·Shyam SundarMadhukar Rai
Sep 3, 2011·Current Opinion in Infectious Diseases·Dinesh Mondal, Md Gulam Musawwir Khan
Nov 10, 2012·Tropical Medicine & International Health : TM & IH·Shyam SundarByron Arana

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