Amphotericin B-silver hybrid nanoparticles: synthesis, properties and antifungal activity

Nanomedicine : Nanotechnology, Biology, and Medicine
Krzysztof TutajWieslaw I Gruszecki

Abstract

High antifungal activity is reported, in comparison with commercially available products, of a novel hybrid system based on silver nanoparticles synthesized using a popular antifungal macrocyclic polyene amphotericin B (AmB) acting both as a reducing and stabilizing/capping agent. The synthesis reaction proceeds in an alkaline environment which prevents aggregation of AmB itself and promotes nanoparticle formation. The innovative approach produces monodisperse (PDI=0.05), AmB-coated silver nanoparticles (AmB-AgNPs) with the diameter ~7nm. The products were characterized using imaging (electron microscopy) and spectroscopic (UV-vis and infrared absorption, dynamic light scattering and Raman scattering) methods. The nanoparticles were tested against Candida albicans, Aspergillus niger and Fusarium culmorum species. For cytotoxicity studies CCD-841CoTr and THP-1 cell lines were used. Particularly high antifungal activity of AmB-AgNPs is interpreted as the result of synergy between the antifungal activity of amphotericin B and silver antimicrobial properties (Ag(+) ions release). Amphotericin B (AmB) is a common agent used for the treatment against severe fungal infections. In this article, the authors described a new approach in u...Continue Reading

References

Nov 1, 1992·Antimicrobial Agents and Chemotherapy·P LegrandJ Bolard
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·P M LoiseauI De Miguel
Jul 22, 2004·Bioconjugate Chemistry·Catherine M GoodmanVincent M Rotello
Aug 2, 2005·Journal of Colloid and Interface Science·Marcela M OliveiraAldo J G Zarbin
Oct 16, 2008·Biotechnology Advances·Mahendra RaiAniket Gade
Dec 15, 2010·ACS Nano·Monica BenincasaRenato Gennaro
Jul 2, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Fidel Martínez-GutierrezHoracio Bach
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kaitlyn C GrayMartin D Burke
Apr 25, 2012·Annual Review of Biomedical Engineering·Alexandre AlbaneseWarren C W Chan
Aug 29, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Miguel M LinoLino S Ferreira
Jan 18, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Keerti JainNarendra Kumar Jain
Mar 27, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Michael GrossuttiJacek Lipkowski

❮ Previous
Next ❯

Citations

Oct 22, 2016·MedChemComm·Huy X NgoKeith D Green
Nov 4, 2016·The Journal of Physical Chemistry. B·Marta ArczewskaMariusz Gagoś
Oct 30, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Fatemeh ElahianSeyed Abbas Mirzaei
Sep 22, 2017·Current Medicinal Chemistry·Aleksandra HecelHenryk Kozlowski
Aug 12, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Gudepalya Renukaiah Rudramurthy, Mallappa Kumara Swamy
Jun 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francis J OsongaOmowunmi A Sadik
Dec 13, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Prateek MathurN K Jain
Oct 31, 2018·Open Life Sciences·Agnieszka Pudlarz, Janusz Szemraj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

© 2022 Meta ULC. All rights reserved