Amphotericin B toxicity as related to the formation of oxidatively modified low-density lipoproteins

Biospectroscopy
J BarwiczI Gruda

Abstract

The effect of amphotericin B on the oxidation and degradation of low- and high-density lipoproteins was investigated by UV-vis spectroscopy, electron microscopy, electrophoresis, and size-exclusion chromatography. Two formulations of the drug were used: the commercial Fungizone and a new, less toxic, liposomal formulation, AmBisome. It was shown that Fungizone strongly enhanced the oxidative deformation of low-density lipoprotein structure while AmBisome did not bind to this lipoprotein fraction and did not affect its oxidation. It was shown that amphotericin B contained in Fungizone extracted cholesterol from low-density lipoproteins which sensitized them to oxidation. Both formulations of amphotericin B studied here did not bind to high-density lipoprotein and did not affect the process of its oxidation.

References

Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Jan 9, 1991·Biochimica Et Biophysica Acta·M Bonilla-MarínI Ortega-Blake
Dec 16, 1991·Biochemical and Biophysical Research Communications·J BarwiczI Gruda
Oct 1, 1991·The Journal of Antimicrobial Chemotherapy·R ChopraA H Goldstone
Jan 1, 1989·Free Radical Biology & Medicine·N J Schisler, S M Singh
Jul 1, 1986·The Journal of Infectious Diseases·M L Sokol-AndersonG Medoff
May 10, 1974·Annals of the New York Academy of Sciences·T E Andreoli
Jun 1, 1984·The Journal of Infectious Diseases·J BrajtburgG Medoff
Jul 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H HughesJ R Guyton
May 1, 1994·Archives of Biochemistry and Biophysics·Y KawabeT Kodama
Feb 1, 1993·Journal of Pharmaceutical Sciences·M T Lamy-FreundS Schreier
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·K M WasanG Lopez-Berestein

❮ Previous
Next ❯

Citations

Aug 15, 2001·Pharmacotherapy·R E Lewis, D P Kontoyiannis
Nov 11, 2014·Critical Reviews in Microbiology·Maria Elisa RodriguesMariana Henriques
Dec 7, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ricardo Díaz de León-OrtegaNikoletta Fotaki
Apr 3, 2007·Molecular Pharmaceutics·Cécile MénezGillian Barratt
Feb 12, 2011·Microbes and Infection·Fernanda Sangalli-LeiteOscar Zaragoza

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.