Amphotericin B/emulsion admixture interactions: an approach concerning the reduction of amphotericin B toxicity

Journal of Pharmaceutical Sciences
E Sócrates T EgitoJames C Price

Abstract

Mixing Fungizone with a fat emulsion used for nutritional purpose (Intralipid or Lipofundin ) was reported to decrease Amphotericin B (AmB) toxicity in clinical use. In an effort to understand the reason for this phenomenon, spectral and morphological analyses were done for the Fungizone and Fungizone /Lipofundin admixture (FLmix). The absorption spectra analyses showed that not only Fungizone but also FLmix presented spectra that were concentration dependent. Moreover, the spectra of FLmix remained stable until the concentration of 5 x 10(-7) M, and only at 5 x 10(-8) M did they become similar in shape to the Fungizone spectra. Morphological studies revealed that even though emulsion droplets with or without Fungizone presented the same particle size, the former was less electron dense compared with Lipofundin alone. These results suggest a kind of association between Fungizoneand Lipofundin that remains over the whole range of concentrations. This hypothesis was confirmed by in vitro studies in which FLmix presented an important selectivity against human and fungal cells compared with Fungizone. These findings suggest that parenteral emulsions should be able to reduce the AmB toxicity probably by changing the AmB self-associa...Continue Reading

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Citations

Jan 26, 2012·International Journal of Nanomedicine·Miguel Adelino da Silva-FilhoEryvaldo Sócrates Tabosa do Egito
Apr 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sóstenes MistroRoberto Badaró
Oct 20, 2004·Drug Development and Industrial Pharmacy·Verica RisovicKishor M Wasan
Jun 26, 2012·Expert Opinion on Drug Delivery·Guilherme CarneiroLucas Antônio Miranda Ferreira
Dec 5, 2009·Journal of Drug Targeting·Lourena Mafra VerissimoE Sócrates Tabosa do Egito
May 5, 2004·Journal of Pharmaceutical Sciences·Lucila C M EgitoE Sócrates T Egito
Feb 11, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Leila Rodrigues CaldeiraLucas Antônio Miranda Ferreira
Sep 28, 2005·Acta Cirúrgica Brasileira·Ivonete Batista AraújoE Sócrates T Egito
Oct 19, 2017·Journal of Drug Targeting·Délia Chaves Moreira Dos SantosMarta Marques Gontijo Aguiar
Oct 27, 2007·Pharmaceutical Development and Technology·J-U JunghannsB P G L Damasceno
Apr 3, 2007·Molecular Pharmaceutics·Cécile MénezGillian Barratt

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