Amphotericin B/emulsion admixture interactions: an approach concerning the reduction of amphotericin B toxicity

Journal of Pharmaceutical Sciences
E Sócrates T EgitoJames C Price


Mixing Fungizone with a fat emulsion used for nutritional purpose (Intralipid or Lipofundin ) was reported to decrease Amphotericin B (AmB) toxicity in clinical use. In an effort to understand the reason for this phenomenon, spectral and morphological analyses were done for the Fungizone and Fungizone /Lipofundin admixture (FLmix). The absorption spectra analyses showed that not only Fungizone but also FLmix presented spectra that were concentration dependent. Moreover, the spectra of FLmix remained stable until the concentration of 5 x 10(-7) M, and only at 5 x 10(-8) M did they become similar in shape to the Fungizone spectra. Morphological studies revealed that even though emulsion droplets with or without Fungizone presented the same particle size, the former was less electron dense compared with Lipofundin alone. These results suggest a kind of association between Fungizoneand Lipofundin that remains over the whole range of concentrations. This hypothesis was confirmed by in vitro studies in which FLmix presented an important selectivity against human and fungal cells compared with Fungizone. These findings suggest that parenteral emulsions should be able to reduce the AmB toxicity probably by changing the AmB self-associa...Continue Reading


Oct 1, 1992·Antimicrobial Agents and Chemotherapy·J BarwiczI Gruda
Nov 1, 1992·Antimicrobial Agents and Chemotherapy·P LegrandJ Bolard
Apr 1, 1991·Antimicrobial Agents and Chemotherapy·J M ClarkD P Bonner
May 1, 1988·The Journal of Pharmacy and Pharmacology·D ForsterS S Davis
Jan 1, 1987·Annals of the New York Academy of Sciences·S S DavisR Kirsh
Apr 1, 1971·The Journal of Infectious Diseases·W T Butler, E Cotlove
Nov 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·C P Thakur
Oct 10, 1993·Biochimica Et Biophysica Acta·H E LambingS C Hartsel
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W Hiemenz, T J Walsh
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H A Gallis
Jul 1, 1996·The Journal of Antimicrobial Chemotherapy·V JolyP Yeni
Sep 1, 1996·The Journal of Antimicrobial Chemotherapy·E S Tabosa Do EgitoJ P Devissaguet
Dec 1, 1996·Trends in Pharmacological Sciences·S Hartsel, J Bolard
May 1, 1997·The Journal of Antimicrobial Chemotherapy·Y ShadkhanD Lichtenberg
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Wong-BeringerB J Guglielmo
Jul 8, 1999·Chemotherapy·B E de Pauw, F Meunier

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