PMID: 602944Jan 1, 1977Paper

Amphotericin inhibition of hematopoiesis in vitro

American Journal of Hematology
H P Koeffler, D W Golde

Abstract

The effect of amphotericin B on human and murine hematopoiesis was studied in vitro using assays for erythroid and myeloid colony-forming cells. Amphotericin consistently inhibited colony formation by erythroid and granulocyte-monocyte progenitor cells. Clear effects were observable at amphotericin concentrations of 1.0 microgram/ml, and concentrations of 2.0 microgram/ml caused approximately 50-60% inhibition of cloning of both murine and normal human bone marrow. These data suggest that amphotericin, in concentrations achieved in therapy, can impair hematopoiesis by a direct effect on precursor cells.

References

Jan 1, 1976·The Journal of Clinical Investigation·D W GoldeM J Cline
Jan 1, 1976·American Journal of Hematology·D W GoldeM J Cline
Mar 1, 1976·Journal of the National Cancer Institute·F ValerioteB V Kumar
Feb 7, 1974·The New England Journal of Medicine·J E Bennett
Jan 3, 1974·The New England Journal of Medicine·J E Bennett
Nov 1, 1972·The Journal of Clinical Investigation·D W Golde, M J Cline
Apr 1, 1971·The Journal of Infectious Diseases·W T Butler, E Cotlove
Dec 1, 1971·The Australian Journal of Experimental Biology and Medical Science·T R BradleyM A Sumner
Dec 1, 1969·Annals of Internal Medicine·R P Miller, J H Bates
Oct 1, 1969·The Journal of Infectious Diseases·D D Bindschadler, J E Bennett
Aug 1, 1968·The Journal of General Physiology·T E Andreoli, M Monahan
Sep 1, 1968·The American Journal of Medicine·D J DrutzM G Koenig
Aug 31, 1964·JAMA : the Journal of the American Medical Association·M W BRANDRISSF STOHLMAN
Aug 1, 1964·Annals of Internal Medicine·J P UTZ

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Citations

Jan 1, 1983·Antimicrobial Agents and Chemotherapy·T C MeekerR W McGuffin
Dec 1, 1979·The Journal of Clinical Investigation·J Misiti, J L Spivak
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C M HawrylowiczB W Hancock

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