PMID: 15247600Jul 13, 2004Paper

Ampicillin and penicillin concentration in serum and pleural fluid of hospitalized children with community-acquired pneumonia

The Pediatric Infectious Disease Journal
Gustavo GiachettoA M Ferrari

Abstract

Optimal therapeutic efficacy of beta-lactam antibiotics for treatment of pneumococcal pneumonia is thought to be associated with the serum concentration greater than the minimum inhibitory concentration for 40-50% of the interdose interval at site of infection. Establish whether intravenous administration of ampicillin 400 mg/kg/day or penicillin 200,000 IU/kg/day in 6 divided doses reaches serum and or pleural concentrations above 4 microg/ml for at least 40% of the interdose interval. Hospitalized healthy children 1 month-14 years old with community-acquired bacterial pneumonia and empyema were eligible. Blood samples were obtained 30 min (C1) and 3 h (C2) after an antibiotic dose. Pleural fluid samples were obtained 1 and 4 h after the same dose in which blood samples were obtained. The concentrations were measured by high performance liquid chromatography. The study included 17 patients treated with ampicillin and 13 treated with penicillin. For ampicillin, mean serum concentrations were C1 37.3 +/- 19 microg/ml and C2 11 +/- 10.2 microg/ml and mean pleural fluid concentrations were C1 25.8 +/- 9.9 microg/ml and C2 16.2 +/- 7.9 microg/ml. For penicillin, mean serum concentrations were C1 21.8 +/- 16.4 microg/ml and C2 23.9 ...Continue Reading

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Citations

Apr 3, 2012·The Pediatric Infectious Disease Journal·Susanna EspositoUrs B Schaad
Mar 21, 2007·Antimicrobial Agents and Chemotherapy·Tuuli MetsvahtIrja Lutsar
Jun 2, 2018·Blood·Hannah YanKatherine Y King
Apr 21, 2021·Revista Argentina de microbiología·Martha von SpechtHoracio A Lopardo

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