Ampicillin Nanoparticles Production via Supercritical CO2 Gas Antisolvent Process

AAPS PharmSciTech
Nadia Esfandiari, Seyyed M Ghoreishi

Abstract

The micronization of ampicillin via supercritical gas antisolvent (GAS) process was studied. The particle size distribution was significantly controlled with effective GAS variables such as initial solute concentration, temperature, pressure, and antisolvent addition rate. The effect of each variable in three levels was investigated. The precipitated particles were analyzed with scanning electron microscopy (SEM) and Zetasizer Nano ZS. The results indicated that decreasing the temperature and initial solute concentration while increasing the antisolvent rate and pressure led to a decrease in ampicillin particle size. The mean particle size of ampicillin was obtained in the range of 220-430 nm by varying the GAS effective variables. The purity of GAS-synthesized ampicillin nanoparticles was analyzed in contrast to unprocessed ampicillin by FTIR and HPLC. The results indicated that the structure of the ampicillin nanoparticles remained unchanged during the GAS process.

References

Oct 24, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S MoshashaéeP York
Jan 15, 2008·Advanced Drug Delivery Reviews·K ByrappaT Adschiri
Jul 7, 2009·International Journal of Pharmaceutics·Kunikazu MoribeKeiji Yamamoto

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Citations

Oct 17, 2018·Mini Reviews in Medicinal Chemistry·Maobin XieYi Li
Jun 25, 2019·Current Medicinal Chemistry·Bruno Fonseca-SantosMarlus Chorilli

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