Ampicillin resistance of invasive Haemophilus influenzae isolates in Germany 2009-2012

International Journal of Medical Microbiology : IJMM
Thiên-Trí LâmUlrich Vogel

Abstract

In this retrospective study covering a four-year observation period (2009-2012) the prevalence of aminopenicillin resistance of invasive Haemophilus influenzae (Hi) in Germany was analyzed. The main resistance mechanism against aminopenicillins is conferred by β-lactamase production, which can be inhibited by clavulanate or sulbactam. Apart from that, β-lactamase negative ampicillin resistance (BLNAR) has been reported due to mutations in the penicillin-binding protein PBP3. The prevalence of BLNAR varies considerably in different countries. Representative data from Germany have not been reported. We analyzed 704 culture positive cases with bacteraemia or detection of Hi in cerebrospinal fluid; 82 isolates (11.6%) were phenotypically resistant to ampicillin. Among these isolates, 65 (79.3%) showed β-lactamase production, and 17 isolates (20.7%) were phenotypic BLNAR Hi. The proportion of ampicillin resistant isolates remained stable over the observation period. Analysis of the PBP3 sequences of 133 isolates with different susceptibility phenotypes including susceptible, BLNAR, and β-lactamase positive isolates, revealed a high genetic diversity. Previously described PBP3 mutations were associated to elevated MIC values, albeit ...Continue Reading

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Citations

Sep 14, 2015·International Journal of Medical Microbiology : IJMM·Ulrich VogelMary Slack
Mar 17, 2017·Journal of Chemotherapy·Francesco BlasiUNKNOWN On behalf of the *MASTER working group
Mar 28, 2019·Pathogens and Disease·Noor Marian MudaUlrike Kappler
Mar 17, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Catarina Isabel Moreira HeliodoroUNKNOWN Portuguese Group for the Study of Haemophilus influenzae invasive infection
Sep 6, 2019·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Hong-Jiao WangXue-Jun Chen
Apr 22, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B OlzowyUNKNOWN Working Party ‘Antimicrobial Resistance’ of the Paul-Ehrlich-Society for Chemotherapy
Jul 9, 2020·Enfermedades infecciosas y microbiología clínica·Maitane Ibar-BariainAndrés Canut-Blasco

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