AMPK: a key regulator of energy balance in the single cell and the whole organism

International Journal of Obesity : Journal of the International Association for the Study of Obesity
D G Hardie

Abstract

The AMP-activated protein kinase (AMPK) system is a key player in regulating energy balance at both the cellular and whole-body levels, placing it at centre stage in studies of obesity, diabetes and the metabolic syndrome. It is switched on in response to metabolic stresses such as muscle contraction or hypoxia, and modulated by hormones and cytokines affecting whole-body energy balance such as leptin, adiponectin, resistin, ghrelin and cannabinoids. Once activated, it switches on catabolic pathways that generate adenosine triphosphate (ATP), while switching off ATP-consuming anabolic processes. AMPK exists as heterotrimeric complexes comprising a catalytic alpha-subunit and regulatory beta- and gamma-subunits. Binding of AMP to the gamma-subunit, which is antagonized by high ATP, causes activation of the kinase by promoting phosphorylation at threonine (Thr-172) on the alpha-subunit by the upstream kinase LKB1, allowing the system to act as a sensor of cellular energy status. In certain cells, AMPK is activated in response to elevation of cytosolic Ca2+ via phosphorylation of Thr-172 by calmodulin-dependent kinase kinase-beta (CaMKKbeta). Activation of AMPK, either in response to exercise or to pharmacological agents, has cons...Continue Reading

References

Aug 18, 2001·Journal of Applied Physiology·D ZhengG L Dohm
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Haihong ZongGerald I Shulman
Feb 19, 2003·The Biochemical Journal·Gabriela da Silva XavierGuy A Rutter
Nov 15, 2003·Current Biology : CB·Angela WoodsDavid Carling
Jan 15, 2004·The Journal of Clinical Investigation·John W ScottD Grahame Hardie
Jan 27, 2004·The Journal of Biological Chemistry·Ulrika AnderssonCaroline J Small
Mar 17, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P SchrauwenM K C Hesselink
Mar 26, 2004·Reviews in Endocrine & Metabolic Disorders·D Grahame Hardie
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pawel DobrzynJames M Ntambi
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
Jun 28, 2005·The Journal of Biological Chemistry·Rebecca L HurleyLee A Witters
Jan 25, 2006·The Journal of Biological Chemistry·Naoto KubotaTakashi Kadowaki
Jun 8, 2006·Annual Review of Biochemistry·Dario R AlessiJose R Bayascas
Jul 5, 2006·The Journal of Experimental Medicine·Peter TamásDoreen A Cantrell

❮ Previous
Next ❯

Citations

Mar 1, 1982·Neurochemical Research·B F Roth-Schechter, G Tholey
Jan 29, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Eric GuévélouCharlotte Corporeau
Aug 30, 2011·Apoptosis : an International Journal on Programmed Cell Death·Angela M FarrellyMaria M Byrne
Nov 15, 2011·Cell Death and Differentiation·M DagenaisM Saleh
May 9, 2013·Nature Medicine·Maryam AhmadianRonald M Evans
Oct 18, 2011·The Journal of Biological Chemistry·Diego A MirandaDavid L Silver
Feb 22, 2013·The Journal of Biological Chemistry·Matthew A LorenzCharles F Burant
Aug 18, 2010·Antioxidants & Redox Signaling·Petronela WeisováJochen H M Prehn
May 26, 2010·Clinical and Experimental Pharmacology & Physiology·Sheng-Yang JiangYou-Yi Zhang
Feb 28, 2009·Acta Physiologica·B D HegartyE W Kraegen
Feb 13, 2009·American Journal of Physiology. Cell Physiology·Kenneth R HallowsNúria M Pastor-Soler
Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Marta A PaivaMihaela M Mocanu
Feb 26, 2010·American Journal of Physiology. Renal Physiology·Kenneth R HallowsDavid A Power
Oct 30, 2010·Journal of Applied Physiology·James A Timmons
Feb 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Woong Sun Jang, Se Young Choung
Jul 12, 2011·Cancer Research·Renée F JohnsonNeil D Perkins
Jul 4, 2013·BMC Cancer·Mingo Ming Ho YungHextan Yuen-Sheung Ngan
Apr 12, 2012·Journal of Lipid Research·Joo-Won LeeJae Bum Kim
Dec 3, 2008·Journal of Lipid Research·Salih J Wakil, Lutfi A Abu-Elheiga
Jul 18, 2009·Endocrinology·Susana Sangiao-AlvarellosCarlos Diéguez
Jun 1, 2010·The Journal of Experimental Biology·Gregory L FlorantRobert J Handa
Apr 12, 2011·PloS One·Yasuhiko MatsumotoKazuhisa Sekimizu
Jul 23, 2014·PloS One·Mamoru KamoshitaKazuo Tsubota

❮ Previous
Next ❯

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