AMPK, Mitochondrial Function, and Cardiovascular Disease.

International Journal of Molecular Sciences
Shengnan Wu, Ming-Hui Zou

Abstract

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine triphosphate levels in response to energetic and/or cellular stress. In addition to its conventional roles as an intracellular energy switch or fuel gauge, emerging research has shown that AMPK is also a redox sensor and modulator, playing pivotal roles in maintaining cardiovascular processes and inhibiting disease progression. Pharmacological reagents, including statins, metformin, berberine, polyphenol, and resveratrol, all of which are widely used therapeutics for cardiovascular disorders, appear to deliver their protective/therapeutic effects partially via AMPK signaling modulation. The functions of AMPK during health and disease are far from clear. Accumulating studies have demonstrated crosstalk between AMPK and mitochondria, such as AMPK regulation of mitochondrial homeostasis and mitochondrial dysfunction causing abnormal AMPK activity. In this review, we begin with the description of AMPK structure and regulation, and then focus on the recent advances toward understanding how mitochondrial dysfunction controls AMPK and how AMPK, as a central mediator o...Continue Reading

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Citations

Dec 15, 2020·Experimental Gerontology·Mohammad A UddinNektarios Barabutis
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Qiuhua YangYuqing Huo
Dec 31, 2020·International Journal of Molecular Sciences·Alessandra Ferramosca
Feb 14, 2021·Environmental Toxicology and Pharmacology·Lucia RackovaZuzana Brnoliakova
May 4, 2021·Drugs·Sajad DehnaviAmirhossein Sahebkar
Apr 17, 2021·Proteomics·Bethany ClaridgeDavid W Greening
Jun 8, 2021·Oxidative Medicine and Cellular Longevity·Shiyu SongLi Kong
Jun 26, 2021·Frontiers in Cell and Developmental Biology·Qiang ZhaoMing-Hui Zou
Jul 3, 2021·International Journal of Molecular Sciences·Isabella PanfoliDavide Maggi
Aug 28, 2021·International Journal of Molecular Sciences·Diana SalnikovaAlexander Orekhov

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Methods Mentioned

BETA
nuclear translocation

Software Mentioned

MitoParaquat

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