Ampli: A Construction Set for Paperfluidic Systems

Advanced Healthcare Materials
Elizabeth A PhillipsJose Gomez-Marquez

Abstract

The design and fabrication of reconfigurable, modular paperfluidics driven by a prefabricated reusable block library, asynchronous modular paperfluidic linear instrument-free (Ampli) block, are reported. The blocks are inspired by the plug-and-play modularity of electronic breadboards that lower prototyping barriers in circuit design. The resulting biochemical breadboard is a paperfluidic construction set that can be functionalized with chemical, biological, and electrical elements. Ampli blocks can form standard paperfluidic devices without any external instrumentation. Furthermore, their modular nature enhances fluidics in ways that fixed devices cannot. The blocks' ability to start, stop, modify, and reverse reaction flows, reagents, and rates in real time is demonstrated. These enhancements allow users to increase colorimetric signals, fine tune reaction times, and counter check multiplexed diagnostics for false positives or negatives. The modular construction demonstrates that field-ready, distributed fabrication of paper analytical systems can be standardized without requiring the "black box" of craft and technique inherent in paper-based systems. Ampli assembly and point-of-care redesign extends the usability of paper an...Continue Reading

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Citations

Apr 16, 2019·Frontiers in Bioengineering and Biotechnology·Salomón Marquez, Eden Morales-Narváez
Feb 1, 2019·Sensors·Delyan R HristovKimberly Hamad-Schifferli
Aug 20, 2019·Advanced Healthcare Materials·Jose Gomez-Marquez, Kimberly Hamad-Schifferli
Apr 6, 2021·Chemtexts·Laura M HillscherHarald Kolmar
Apr 15, 2021·Analytical and Bioanalytical Chemistry·Lara P MurrayCharles R Mace
May 27, 2021·Analytical Chemistry·Delyan HristovKimberly Hamad-Schifferli

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