PMID: 8601533Apr 1, 1995Paper

Amplification and expression of the c-erbB-2 oncogene in normal, hyperplastic, and malignant endometria

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
K CzerwenkaF Heuss

Abstract

Using differential polymerase chain reaction (DPCR), dot blot hybridization, and an immunohistochemical technique, we determined the amplification and expression of the c-erbB-2 oncogene in 25 normal, 31 hyperplastic, and 72 malignant samples of the endometrium in 128 patients. Using DPCR, we found amplified c-erbB-2 (two to 12 copies) in two of 25 (8%) normal, 15 of 31 (48%) hyperplastic, and 45 of 72 (63%) malignant samples. These results were closely correlated with those from dot blot (r = 0.78). When comparing the results of DPCR with those of the immunohistochemical method, we noted that the negative findings coincided with one another, i.e., nonamplification was associated with the absence of immunoreactivity. Further analysis showed that amplified c-erbB-2 was found significantly more in complex and atypical hyperplasias versus simple hyperplasias. This indicates that c-erbB-2 may play a potential role in the early development of some endometrial carcinomas. Although no correlation was seen between c-erbB-2 amplification and overall survival in our patients, high-level c-erbB-2 amplification (at least five copies) was significantly associated with the histological grade of endometrial carcinoma and vascular or lymphatic...Continue Reading

Citations

Jan 1, 1996·Breast Cancer Research and Treatment·K CzerwenkaE Kubista
Sep 25, 2002·Maturitas·Hugo MaiaElsimar M Coutinho
Jun 21, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Georgia VoglCornelia Hauser-Kronberger
Aug 12, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B B Y MaA Fyles
Mar 28, 2003·Wiener klinische Wochenschrift·Darko JelincicKlaus Czerwenka
Mar 17, 2007·Pathology·Annie N Y Cheung
Dec 5, 2003·Nature Reviews. Drug Discovery·Guido SauterKenneth Hillan
Sep 25, 2007·Onkologie·Maria LambropoulouNikolas Papadopoulos
Aug 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ivana MarkovaRadovan Pilka
Jul 25, 2013·British Journal of Cancer·T H-Y LeungH Y-S Ngan
May 20, 2014·Molecular Carcinogenesis·Takuya KitamuraKaoru Kiguchi
Jun 5, 2014·Journal of Hepato-biliary-pancreatic Sciences·Kosei MaemuraSonshin Takao
Nov 24, 2006·Molecular Cancer Therapeutics·Elizabeth E EvansMaurice Zauderer

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