Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice

ELife
Mina L KojimaDavid C Page

Abstract

The germ line provides the cellular link between generations of multicellular organisms, its cells entering the meiotic cell cycle only once each generation. However, the mechanisms governing this initiation of meiosis remain poorly understood. Here, we examined cells undergoing meiotic initiation in mice, and we found that initiation involves the dramatic upregulation of a transcriptional network of thousands of genes whose expression is not limited to meiosis. This broad gene expression program is directly upregulated by STRA8, encoded by a germ cell-specific gene required for meiotic initiation. STRA8 binds its own promoter and those of thousands of other genes, including meiotic prophase genes, factors mediating DNA replication and the G1-S cell-cycle transition, and genes that promote the lengthy prophase unique to meiosis I. We conclude that, in mice, the robust amplification of this extraordinarily broad transcription program by a common factor triggers initiation of meiosis.

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Citations

Nov 2, 2019·Andrology·Rachel GewissMichael D Griswold
Nov 28, 2019·Biomolecules·Tsutomu EndoDirk G de Rooij
Aug 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Wanbao Niu, Allan C Spradling
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Datasets Mentioned

BETA
KX981576.1
GSE115928

Methods Mentioned

BETA
RNA-seq
ChIP-seq
ChIP
PCR
genotyping
KO
biopsy
Fluorescence
immunoprecipitation

Software Mentioned

bamcompare
tximport
BLAST
count
plot
scanMotifGenomeWide . pl
PANTHER over representation test
deepTools
RStudio
PHYLIP

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